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- Table of Contents
Facts about NEDD8-activating enzyme E1 regulatory subunit.
E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint.
Human | |
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Gene Name: | NAE1 |
Uniprot: | Q13564 |
Entrez: | 8883 |
Belongs to: |
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ubiquitin-activating E1 family |
A-116A10.1; amyloid beta precursor protein binding protein 1; amyloid beta precursor protein binding protein 1, 59kDa; Amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid beta precursor protein-binding protein 1, 59kD; Amyloid protein-binding protein 1; APPBP1APP-BP1; NEDD8 Activating Enzyme (APPBP1/UBA3); NEDD8 activating enzyme E1 subunit 1; NEDD8-activating enzyme E1 regulatory subunit; NEDD8-activating enzyme E1 subunit; protooncogene protein 1; Proto-oncogene protein 1; ula-1
Mass (kDA):
60.246 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (66802878..66830977, complement) |
Ubiquitous in fetal tissues. Expressed throughout the adult brain.
Cell membrane. Colocalizes with APP in lipid rafts.
PMID: 8626687 by Chow N., et al. APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.
PMID: 10207026 by Gong L., et al. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.