Myotilin Antibodies

AND MYOT ELISA kits, Myotilin Proteins

Many biological assays use antibodies to detect Myotilin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Myotilin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Myotilin antibodies...

We validate the specificity of these antibodies to Myotilin by testing them on tissues known to express MYOT positively and negatively. Browse below to find the MYOT antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MYOT Infographic by Boster Bio

All MYOT Products

Product

Figures

Specificity

Applications

Price

Anti-Myotilin MYOT Antibody

Human, Mouse, Rat

IF, IHC, WB

$405
Cat # A04663
100ul

Anti-Myotilin (MYOT) Mouse Monoclonal Antibody [Clone ID: OTI5E11]

Human, Mouse, Rat

IHC, WB

$523
Cat # M04663
100 µl

Myotilin (MYOT) (NM_006790) Human Over-expression Lysate

Human

$628
Cat # LS009499
100 µg

Anti-MYOT Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04663-2
100 µg/vial

MYOT Overview

Facts about Myotilin.

MYOT 3D structure. Source: alphafold

Myotilin (MYOT)

Component of a complex of numerous actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the lines in muscle cells.

Gene Information

Human
Gene Name:	MYOT
Uniprot:	Q9UBF9
Entrez:	9499

Family

Belongs to:

myotilin/palladin family

Alternative Names

57 kDa cytoskeletal protein; LGMD1A; limb-girdle muscular dystrophy 1A (autosomal dominant); Myofibrillar titin-like Ig domains protein; myotilin; titin immunoglobulin domain protein (myotilin); Titin immunoglobulin domain protein; TTIDLGMD1

Molecular Weight

Mass (kDA):
55.395 kDA

Genomic Context


Human

Location:	5q31.2
Sequence:	5; NC_000005.10 (137867282..137887851)

Tissue Specificity

Expressed in skeletal muscle (at protein level). Expressed in skeletal muscle, heart, bone marrow and thyroid gland.

Subcellular Localizations

Cell membrane, sarcolemma. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Sarcomeric, also localized to the sarcolemma (PubMed:10369880). Colocalizes with MYOZ1 at the Z-lines in skeletal muscle (PubMed:16076904).

Diseases

Myopathy
Muscular Dystrophy
Dystrophy
Muscular Dystrophies, Limb-girdle
Weakness
Distal Muscular Dystrophies
Muscle Weakness
Cardiomyopathies
Neuromuscular Diseases
Myopathies, Nemaline

Peripheral Neuropathy
Hypertrophy
Congenital Structural Myopathy
Heart Failure
Respiratory Failure

Interacting Proteins

ACTN2
FLNC
NME7

Pathways

Pathogenesis
Localization
Myofibril Assembly
Regulation Of Muscle Contraction
Cell Motility
Protein Folding
Sarcomere Organization
Proteolysis

Muscle Contraction
Apoptotic Nuclear Changes
Muscle Atrophy

PTMs

Phosphorylation
Nitration

Cleavage
Oxidation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYOT

References

PMID: 10486214 by Godley L.A., et al. TTID: a novel gene at 5q31 encoding a protein with titin-like features.

PMID: 10369880 by Salmikangas P., et al. Myotilin, a novel sarcomeric protein with two Ig-like domains, is encoded by a candidate gene for limb-girdle muscular dystrophy.