Thrombopoietin receptor Antibodies

AND MPL ELISA kits, Thrombopoietin receptor Proteins

Many biological assays use antibodies to detect Thrombopoietin receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Thrombopoietin receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Thrombopoietin receptor antibodies...

We validate the specificity of these antibodies to Thrombopoietin receptor by testing them on tissues known to express MPL positively and negatively. Browse below to find the MPL antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MPL Infographic by Boster Bio

All MPL Products

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Product

Figures

Specificity

Applications

Price

Mouse TPOR/MPL/Thrombopoietin R ELISA Kit PicoKine®

9 Q&As

Mouse

ELISA

$750
Cat # EK1436
96 wells/kit, with removable strips.

Anti-CD110 MPL Antibody

7 Q&As

Human, Mouse, Rat

IHC, WB

$399
Cat # A00483
100μl

Anti-TPOR Rabbit Monoclonal Antibody

Human, Mouse, Rat

$370
Cat # M00483
100 μl/vial

TPOR (MPL) (NM_005373) Human Over-expression Lysate

Human

$960
Cat # LS004352
100 µg

MPL Overview

Facts about Thrombopoietin receptor.

MPL 3D structure. Source: alphafold

Thrombopoietin receptor (MPL)

Receptor for thrombopoietin that functions as a key regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

Gene Information

Human
Gene Name:	MPL
Uniprot:	P40238
Entrez:	4352

Family

Belongs to:

type I cytokine receptor family

Alternative Names

CD110 antigen; CD110; c-Mpl; MPL; MPLV; Myeloproliferative leukemia protein; myeloproliferative leukemia virus oncogene; Proto-oncogene c-Mpl; Thrombopoietin R; thrombopoietin receptor; TpoR; TPO-R; TPORMPLV

Molecular Weight

Mass (kDA):
71.245 kDA

Genomic Context


Human

Location:	1p34.2
Sequence:	1; NC_000001.11 (43336875..43354466)

Tissue Specificity

Expressed at a low level in a large number of cells of hematopoietic origin. Isoform 1 and isoform 2 are always found to be coexpressed.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cell surface.

Diseases

Thrombocytosis
Myeloproliferative Disease
Neoplasms
Leukemia
Thrombocythemia, Essential
Primary Myelofibrosis
Polycythemia Vera
Polycythemia
Myeloid Leukemia
Malignant Neoplasms
Leukemia, Myelocytic, Acute
Anemia

Thrombosis
Purpura, Thrombocytopenic, Idiopathic
Dysmyelopoietic Syndromes
Janiceps
Myeloid Leukemia, Chronic
Salmonella Infections

Interacting Proteins

JAK2

Pathways

Immune Response
Pathogenesis
Cell Proliferation
Cell Growth
Megakaryocyte Differentiation
Localization
Secretion
Megakaryocyte Development
Platelet Aggregation
Hypersensitivity
Platelet Activation
Cell Cycle
Cell Differentiation

Platelet Formation
Cytokine Production
Nuclear Migration
Transport
Aging
Virulence
Coagulation

PTMs

Phosphorylation
Glycosylation
Cleavage
Methylation
Ubiquitination
Biotinylation

Reduction
Phosphorothioation
Oxidation
Demethylation
Ribosylation
Iodination

Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPL

References

PMID: 1608974 by Vigon I., et al. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

PMID: 8020956 by Mignotte V., et al. Structure and transcription of the human c-mpl gene (MPL).