MBD4 Antibodies

AND MBD4 ELISA kits, MBD4 Proteins

Many biological assays use antibodies to detect MBD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBD4 antibodies...

We validate the specificity of these antibodies to MBD4 by testing them on tissues known to express MBD4 positively and negatively. Browse below to find the MBD4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MBD4 Infographic by Boster Bio

All MBD4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MBD4 Antibody Picoband®

5 Q&As

Human, Mouse, Rat

$370
Cat # PA2042
100 μg/vial

Anti-MBD4/MED1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A03462
100 μg/vial

MBD4 (NM_003925) Human Over-expression Lysate

Human

$960
Cat # LS008930
100 µg

Anti-Mbd4 Antibody Picoband®

Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A03462-1
100 µg/vial

MBD4 Overview

Facts about Methyl-CpG-binding domain protein 4.

MBD4 3D structure. Source: alphafold

Methyl-CpG-binding domain protein 4 (MBD4)

Mismatch-specific DNA N-glycosylase involved in DNA repair.
Has thymine glycosylase activity and is unique for G:T mismatches within methylated and unmethylated CpG websites.

Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity.

Gene Information

Human
Gene Name:	MBD4
Uniprot:	O95243
Entrez:	8930

Family

Belongs to:

No superfamily

Alternative Names

EC 3.2.2.-; G/T mismatch glycosylase; G/U mismatch glycosylase; MBD4; MED1G/5-fluorouracil mismatch glycosylase with biphasic kinetics; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylase; Methyl-CpG-binding endonuclease 1; Methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein

Molecular Weight

Mass (kDA):
66.051 kDA

Genomic Context


Human

Location:	3q21.3
Sequence:	3; NC_000003.12 (129430944..129440179, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Metabolic Bone Disorder
Microsatellite Instability
Colorectal Cancer
Cell Transformation, Neoplastic
Carcinoma
Colorectal Neoplasms
Mutation, Out-of-frame
Carcinogenesis
Malignant Tumor Of Colon
Rett Syndrome
Malignant Neoplasm Of Lung

Turcot Syndrome (disorder)
High-frequency Microsatellite Instability
Malignant Neoplasm Of Stomach
Stomach Neoplasms
Lupus Erythematosus, Systemic
Genomic Instability
Endometrial Polyp

Interacting Proteins

FADD
MLH1

Pathways

Methylation
Mismatch Repair
Dna Methylation
Dna Repair
Demethylation
Dna Demethylation
Pathogenesis
Cell Cycle
Dna Replication
Gene Silencing
Dna Hypomethylation
Chromatin Remodeling
Localization

Cell Growth
Rna Interference
Cell Proliferation
Proteolysis
Drug Resistance
Histone Modification
Spermatogenesis

PTMs

Methylation
Deamination
Demethylation
Acetylation

Phosphorylation
Cleavage
Deacetylation
Oxidation

Reduction

Research Areas

Base Excision Repair
Chromatin Research
DNA Repair
Epigenetics

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBD4

References

PMID: 9774669 by Hendrich B., et al. Identification and characterization of a family of mammalian methyl- CpG binding proteins.

PMID: 10441743 by Hendrich B., et al. Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes.