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MAPKAPK2 Antibodies
AND MAPKAPK2 ELISA kits, MAPKAPK2 Proteins
Many biological assays use antibodies to detect MAPKAPK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPKAPK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPKAPK2 antibodies...
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MAPKAPK2 Infographic by Boster Bio
All MAPKAPK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IF, IHC, WB
$360
Cat # P01193
100 µl
Cat # P01193
100 µl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1349
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1349
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1948
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1948
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2158
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2158
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2616
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2616
1 kit, containing two 96-well plates and all necessary reagents
Human, Monkey, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A01193T222
100ul
Cat # A01193T222
100ul
Human, Mouse, Rat
IP, WB
$370
Cat # M01193-1
100 μl/vial
Cat # M01193-1
100 μl/vial
MAPKAPK2 Overview
Facts about MAP kinase-activated protein kinase 2.
MAP kinase-activated protein kinase 2 (MAPKAPK2)
Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. After stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, resulting in phosphorylation of substrates.
Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAPKAPK2 |
| Uniprot: | P49137 |
| Entrez: | 9261 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAPK2; MAPKAPK-2; mitogen-activated protein kinase-activated protein kinase 2; MK2; Rps6kc1
Molecular Weight
Mass (kDA):
45.568 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (206684905..206734283) |
Tissue Specificity
Expressed in all tissues examined.
Subcellular Localizations
Cytoplasm. Nucleus. Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Ischemia
- Myocardial Ischemia
- Cell Invasion
- Malignant Neoplasm Of Breast
- Arthritis
- Hypertrophy
- Carcinoma
- Mammary Neoplasms
- Inflammation
- Cell Transformation, Neoplastic
- Rheumatoid Arthritis
Interacting Proteins
- HSF1
- HSPB1
- MAPK14
- Mapk14
- Phc2
Pathways
- Cell Death
- Cell Proliferation
- Localization
- Mapk Cascade
- Cell Cycle Arrest
- Inflammatory Response
- Cell Cycle
- Neutrophil Chemotaxis
- Pathogenesis
- Transport
- Chemotaxis
- Drug Resistance
- Cytokine Production
PTMs
- Phosphorylation
- Cleavage
- Nitrosylation
Research Areas
- Breast Cancer
- Cancer
- MAP Kinase Signaling
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPKAPK2
bosterbio.com/bosterbio-gene-info-cards/MAPKAPK2
References
PMID: 8179591 by Zu Y.-L., et al. The primary structure of a human MAP kinase activated protein kinase 2.
PMID: 8280084 by Stokoe D., et al. The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2.