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MADCAM1 Antibodies
AND MADCAM1 ELISA kits, MADCAM1 Proteins
Many biological assays use antibodies to detect MADCAM1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MADCAM1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MADCAM1 antibodies...
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MADCAM1 Infographic by Boster Bio
All MADCAM1 Products
Product
Figures
Specificity
Applications
Price
Mouse
ELISA
$750
Cat # EK1332
96 wells/kit, with removable strips.
Cat # EK1332
96 wells/kit, with removable strips.
Human
ELISA
$750
Cat # EK1687
96 wells/kit, with removable strips.
Cat # EK1687
96 wells/kit, with removable strips.
Dog, Human, Mouse, Rat
WB
$523
Cat # M04227
100 µl
Cat # M04227
100 µl
MADCAM1 Overview
Facts about Mucosal addressin cell adhesion molecule 1.
Mucosal addressin cell adhesion molecule 1 (MADCAM1)
Cell adhesion leukocyte receptor expressed by mucosal venules, helps direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes.
Isoform 2, lacking the mucin-like domain, may be specialized in encouraging integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L- selectin binding. .
Gene Information
| Human | |
|---|---|
| Gene Name: | MADCAM1 |
| Uniprot: | Q13477 |
| Entrez: | 8174 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
hMAdCAM-1; MACAM1; MAdCAM1; MAdCAM-1; mucosal addressin cell adhesion molecule 1; mucosal addressin cell adhesion molecule-1; mucosal vascular addressin cell adhesion molecule 1
Molecular Weight
Mass (kDA):
40.155 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (496486..505343) |
Tissue Specificity
Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Tissue Adhesions
- Inflammation
- Inflammatory Bowel Diseases
- Colitis
- Intestinal Diseases
- Lymphoma
- Autoimmune Reaction
- Extravasation
- Crohn Disease
- Classical Galactosemia
- Ulcerative Colitis
- Diabetes Mellitus
- Ulcer
Pathways
- Cell Adhesion
- Pathogenesis
- Lymphocyte Migration
- Localization
- Immune Response
- Inflammatory Response
- Cell Migration
- Organ Development
- Integrin Activation
- Cell Activation
- Cytokine Production
- Cell Differentiation
- Lactation
PTMs
- Phosphorylation
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MADCAM1
bosterbio.com/bosterbio-gene-info-cards/MADCAM1
References
PMID: 8989586 by Leung E., et al. Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts.
PMID: 8609404 by Shyjan A.M., et al. Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences.