Myelin regulatory factor Antibodies

AND MYRF ELISA kits, Myelin regulatory factor Proteins

Many biological assays use antibodies to detect Myelin regulatory factor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Myelin regulatory factor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Myelin regulatory factor antibodies...

We validate the specificity of these antibodies to Myelin regulatory factor by testing them on tissues known to express MYRF positively and negatively. Browse below to find the MYRF antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MYRF Infographic by Boster Bio

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MYRF Overview

Facts about Myelin regulatory factor.

MYRF 3D structure. Source: alphafold

Myelin regulatory factor (MYRF)

Myelin regulatory factor: Constitutes a precursor of the transcription element. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal element that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832).

Gene Information

Human
Gene Name:	MYRF
Uniprot:	Q9Y2G1
Entrez:	745

Family

Belongs to:

MRF family

Alternative Names

Myelin regulatory factor

Molecular Weight

Mass (kDA):
124.397 kDA

Genomic Context


Human

Location:	11q12.2
Sequence:	11; NC_000011.10 (61752617..61788518)

Tissue Specificity

Expressed in lung, ARPE-19 cell line, brainstem, uterus and, to a lesser extent, in basal ganglion and liver. Weakly expressed in cerebellum and retina.

Subcellular Localizations

[Myelin regulatory factor]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Myelin regulatory factor, N-terminal]: Nucleus. Cytoplasm. Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage.; [Myelin regulatory factor, C-terminal]: Endoplasmic reticulum membrane; Single-pass membrane protein.

Diseases

Encephalitis/encephalopathy, mild, with reversible myelin vacuolization (MMERV)

PTMs

Acetylation

Autocatalytic cleavage

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYRF

References

PMID: 10828591 by Stoehr H., et al. cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein.

PMID: 9615227 by Cooper P.R., et al. Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes.