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MYO7A Antibodies
AND MYO7A ELISA kits, MYO7A Proteins
Many biological assays use antibodies to detect MYO7A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MYO7A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MYO7A antibodies...
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MYO7A Infographic by Boster Bio
All MYO7A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M03915
100 μl
Cat # M03915
100 μl
MYO7A Overview
Facts about Unconventional myosin-VIIa.
Unconventional myosin-VIIa (MYO7A)
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements.
Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor discs.
Gene Information
| Human | |
|---|---|
| Gene Name: | MYO7A |
| Uniprot: | Q13402 |
| Entrez: | 4647 |
Family
| Belongs to: |
|---|
| TRAFAC class myosin-kinesin ATPase superfamily |
Alternative Names
deafness, autosomal dominant 11; deafness, autosomal recessive 2; DFNA11; DFNB2; myosin VIIA; myosin-VIIa; MYOVIIA; MYU7A; USH1Bsevere))
Molecular Weight
Mass (kDA):
254.39 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.5 |
| Sequence: | 11; NC_000011.10 (77128192..77215241) |
Tissue Specificity
Expressed in the pigment epithelium and the photoreceptor cells of the retina. Also found in kidney, liver, testis, cochlea, lymphocytes. Not expressed in brain.
Subcellular Localizations
Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, synapse. In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region (PubMed:8842737). In retinal pigment epithelial cells colocalizes with a subset of melanosomes, displays predominant localization to stress fiber-like structures and some localization to cytoplasmic puncta (PubMed:19643958, PubMed:27331610). Detected at the tip of cochlear hair cell stereocilia (PubMed:21709241). The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin (PubM
Diseases
- Usher Syndrome
- Complete Hearing Loss
- Retinitis Pigmentosa
- Sensorineural Hearing Loss (disorder)
- Retinal Degeneration
- Deafness Congenital
- Blind Vision
- Vestibular Diseases
- Retinal Diseases
- Usher Syndrome, Type I
- Visual Impairment
Pathways
- Localization
- Pathogenesis
- Transport
- Phagocytosis
- Translation
- Cell Differentiation
- Cell Development
- Hair Cell Differentiation
- Cell Adhesion
- Reflex
- Melanosome Transport
- Endocytosis
- Regeneration
PTMs
Research Areas
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYO7A
bosterbio.com/bosterbio-gene-info-cards/MYO7A
References
PMID: 8622919 by Weil D., et al. Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia.
PMID: 8884267 by Chen Z.-Y., et al. Molecular cloning and domain structure of human myosin-VIIa, the gene product defective in usher syndrome 1B.