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- Table of Contents
Facts about Unconventional myosin-Ic.
Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles into the plasma membrane.
Human | |
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Gene Name: | MYO1C |
Uniprot: | O00159 |
Entrez: | 4641 |
Belongs to: |
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TRAFAC class myosin-kinesin ATPase superfamily |
FLJ23903; MMIb; MMI-beta; Myosin I beta; myosin IC; myosin-I beta; myosin-Ic; myr2; NMI; nuclear myosin I
Mass (kDA):
121.682 kDA
Human | |
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Location: | 17p13.3 |
Sequence: | 17; NC_000017.11 (1464186..1492686, complement) |
[Isoform 1]: Cytoplasm. Nucleus. Colocalizes with RNA polymerase II. Absent from nucleoli and does not colocalize with RNA polymerase I. Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription.; [Isoform 2]: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium membrane. Cell projection, ruffle. Cytoplasmic vesicle. Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4
PMID: 9119401 by Crozet F., et al. Cloning of the genes encoding two murine and human cochlear unconventional type I myosins.
PMID: 16133118 by Kysela K., et al. Nuclear distribution of actin and myosin I depends on transcriptional activity of the cell.