N-cym protein Antibodies

AND MYCNOS ELISA kits, N-cym protein Proteins

Many biological assays use antibodies to detect N-cym protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with N-cym protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop N-cym protein antibodies...

We validate the specificity of these antibodies to N-cym protein by testing them on tissues known to express MYCNOS positively and negatively. Browse below to find the MYCNOS antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MYCNOS Infographic by Boster Bio

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MYCNOS Overview

Facts about N-cym protein.

MYCNOS 3D structure. Source: alphafold

N-cym protein (MYCNOS)

Regulates equilibrium of MYCN in neuroblastoma cells by inhibiting GSK3B-mediated MYCN phosphorylation. Inhibits GSK3B action by promoting its phosphorylation in'Ser-9' (PubMed:24391509).

Gene Information

Human
Gene Name:	MYCNOS
Uniprot:	P40205
Entrez:	10408

Family

Belongs to:

No superfamily

Alternative Names

N-cym protein

Molecular Weight

Mass (kDA):
11.733 kDA

Genomic Context


Human

Location:	2p24.3
Sequence:	2; NC_000002.12 (15936265..15942433, complement)

Tissue Specificity

Expressed in the neuronal cells of the cerebrum and cerebellum, spermatocytes of the testis, pancreatic cells and also the heart. Expressed in both primary and metastatic neuroblastomas and in thyroid tumors (at protein level). Expression is associated with poor prognosis in neuroblastoma. Expressed in the fetal brain, lung, liver and kidney at varying low levels.

Subcellular Localizations

Cytoplasm. Nucleus.

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MYCNOS

References

PMID: 1419902 by Armstrong B.C., et al. Isolation and characterization of complementary DNA for N-cym, a gene encoded by the DNA strand opposite to N-myc.

PMID: 24391509 by Suenaga Y., et al. NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas.