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- Table of Contents
Facts about Major vault protein.
Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK.
Human | |
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Gene Name: | MVP |
Uniprot: | Q14764 |
Entrez: | 9961 |
Belongs to: |
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No superfamily |
LRPVAULT1; Lung resistance-related protein; major vault protein
Mass (kDA):
99.327 kDA
Human | |
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Location: | 16p11.2 |
Sequence: | 16; NC_000016.10 (29820394..29848039) |
Present in most normal tissues. Higher expression observed in epithelial cells with secretory and excretory functions, as well as in cells chronically exposed to xenobiotics, such as bronchial cells and cells lining the intestine. Overexpressed in many multidrug-resistant cancer cells.
Cytoplasm. Nucleus, nuclear pore complex. Cytoplasm, perinuclear region. 5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665).
PMID: 7585126 by Scheffer G.L., et al. The drug resistance-related protein LRP is the human major vault protein.
PMID: 11071864 by Lange C., et al. Cloning and initial analysis of the human multidrug resistance- related MVP/LRP gene promoter.