MTTP Antibodies

AND MTTP ELISA kits, MTTP Proteins

Many biological assays use antibodies to detect MTTP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTTP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTTP antibodies...

We validate the specificity of these antibodies to MTTP by testing them on tissues known to express MTTP positively and negatively. Browse below to find the MTTP antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTTP Infographic by Boster Bio

All MTTP Products

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Applications

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Anti-MTTP Antibody Picoband®

1 Q&As

Human, Monkey, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A01715-1
100 μg/vial

Anti-MTTP Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A01715
100ul

MTTP Overview

Facts about Microsomal triglyceride transfer protein large subunit.

MTTP 3D structure. Source: alphafold

Microsomal triglyceride transfer protein large subunit (MTTP)

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).

Gene Information

Human
Gene Name:	MTTP
Uniprot:	P55157
Entrez:	4547

Family

Belongs to:

No superfamily

Alternative Names

88kD); 88kDa); ABL; MGC149819; microsomal triglyceride transfer protein large subunit; microsomal triglyceride transfer protein; MTPMGC149820

Molecular Weight

Mass (kDA):
99.351 kDA

Genomic Context


Human

Location:	4q23
Sequence:	4; NC_000004.12 (99564078..99623997)

Tissue Specificity

Liver and small intestine. Also found in ovary, testis and kidney.

Subcellular Localizations

Endoplasmic reticulum. Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785).

Diseases

Fatty Liver
Steatosis
Abetalipoproteinemia
Steatohepatitis
Malignant Neoplasms
Liver Diseases
Obesity
Inflammation
Hepatitis
Diabetes Mellitus
Neoplasms
Hypercholesterolemia
Heart Diseases

Nonalcoholic Fatty Liver Disease
Liver Carcinoma
Insulin Resistance
Cardiovascular Diseases
Colorectal Cancer
Atherosclerosis
Insulin Sensitivity

Pathways

Secretion
Transport
Pathogenesis
Cholesterol Homeostasis
Intracellular Transport
Secretory Pathway
Localization
Chylomicron Assembly
Regulation Of Cholesterol Homeostasis
Proteolysis
Dna Repair
Dna Methylation
Inflammatory Response

Methylation
Translation
Cell Death
Response To Cholesterol
Fatty Acid Oxidation
Lipid Transport
Vitamin Transport

PTMs

Oxidation
Phosphorylation

Cleavage
Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTTP

References

PMID: 8111381 by Shoulders C.C., et al. Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein.

PMID: 8361539 by Sharp D., et al. Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia.