MTRR Antibodies

AND MTRR ELISA kits, MTRR Proteins

Many biological assays use antibodies to detect MTRR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTRR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTRR antibodies...

We validate the specificity of these antibodies to MTRR by testing them on tissues known to express MTRR positively and negatively. Browse below to find the MTRR antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTRR Infographic by Boster Bio

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MTRR (NM_024010) Human Over-expression Lysate

Human

$960
Cat # LS004552
100 µg

MTRR Overview

Facts about Methionine synthase reductase.

MTRR 3D structure. Source: alphafold

Methionine synthase reductase (MTRR)

Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for use of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance.

Folate pathway donates methyl groups necessary for cellular methylation and impacts different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. .

Gene Information

Human
Gene Name:	MTRR
Uniprot:	Q9UBK8
Entrez:	4552

Family

Belongs to:

No superfamily

Alternative Names

[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing); 5-methyltetrahydrofolate-homocysteine methyltransferase reductase; cblE; EC 1.16.1.8; methionine synthase reductase; methionine synthase reductase, mitochondrial; MGC129643; MSR

Molecular Weight

Mass (kDA):
77.674 kDA

Genomic Context


Human

Location:	5p15.31
Sequence:	5; NC_000005.10 (7851186..7901124)

Tissue Specificity

Found in all tissues tested, particularly abundant in skeletal muscle.

Subcellular Localizations

[Isoform B]: Cytoplasm.; [Isoform A]: Cytoplasm.

Diseases

5,10-methylenetetrahydrofolate Reductase Deficiency
Malignant Neoplasms
Hyperhomocysteinemia
Down Syndrome
Leukemia
Neoplasms
Cholangiocarcinoma
Malignant Neoplasm Of Breast
Congenital Abnormality
Acute Lymphocytic Leukemia
Mammary Neoplasms
Carcinoma
Colorectal Neoplasms

Coronary Artery Disease
L1 Acute Lymphoblastic Leukemia
Colorectal Cancer
Dysequilibrium Syndrome
Folic Acid Deficiency
Carcinogenesis
Spina Bifida

Pathways

Methylation
Dna Methylation
Transport
Pathogenesis
Dna Hypomethylation
Meiosis
Dna Repair
Aging
Chromosome Segregation
Translation
Regeneration
Excretion
Neural Tube Closure

Fertilization
Methotrexate Transport
Tube Formation
Response To Vitamin
Regulation Of Gene Expression
Response To Methotrexate
Spermatogenesis

PTMs

Methylation
Reduction
Acetylation

Phosphorylation
Cleavage
Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTRR

References

PMID: 10564814 by Leclerc D., et al. Molecular cloning, expression and physical mapping of the human methionine synthase reductase gene.

PMID: 9501215 by Leclerc D., et al. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria.