Methionine synthase Antibodies

AND MTR ELISA kits, Methionine synthase Proteins

Many biological assays use antibodies to detect Methionine synthase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Methionine synthase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Methionine synthase antibodies...

We validate the specificity of these antibodies to Methionine synthase by testing them on tissues known to express MTR positively and negatively. Browse below to find the MTR antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTR Infographic by Boster Bio

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Anti-MTR Antibody Picoband®

1 Q&As

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A01140-2
100 μg/vial

MTR Overview

Facts about Methionine synthase.

MTR 3D structure. Source: alphafold

Methionine synthase (MTR)

Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).

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Gene Information

Human
Gene Name:	MTR
Uniprot:	Q99707
Entrez:	4548

Family

Belongs to:

vitamin-B12 dependent methionine synthase family

Alternative Names

5-methyltetrahydrofolate-homocysteine methyltransferase 1; 5-methyltetrahydrofolate-homocysteine methyltransferase; cblG; cobalamin-dependent methionine synthase; EC 2.1.1.13; FLJ33168; FLJ43216,5-methyltetrahydrofolate--homocysteine methyltransferase; FLJ45386; methionine synthase; MS; Vitamin-B12 dependent methionine synthase

Molecular Weight

Mass (kDA):
140.527 kDA

Genomic Context


Human

Location:	1q43
Sequence:	1; NC_000001.11 (236794304..236903981)

Tissue Specificity

Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney.

Subcellular Localizations

Cytoplasm.

Diseases

5,10-methylenetetrahydrofolate Reductase Deficiency
Multiple Sclerosis
Sclerosis
Malignant Neoplasms
Neoplasms
Demyelination
Atrophy
Multiple Sclerosis, Relapsing-remitting
Tissue Damage
Multiple Sclerosis, Chronic Progressive
Edema
Brain Injuries
Cognition Disorders

Impaired Cognition
Demyelinating Diseases
Inflammation
Cholangiocarcinoma
Hyperhomocysteinemia
Brain Neoplasms
Malignant Neoplasm Of Breast

Interacting Proteins

MMACHC

Pathways

Transport
Methylation
Dna Methylation
Myelination
Pathogenesis
Aging
Localization
Segmentation
Cognition
Dna Hypomethylation
Secretion
Mrna Transport
Amino Acid Transport

Dna Repair
Electron Transport
Translation
Senescence
Cell Proliferation
Methanogenesis
Drug Resistance

PTMs

Methylation
Reduction
Cleavage
Oxidation
Phosphorylation
Carboxylation
Phosphorothioation

Dephosphorylation
Acylation
Iodination
Nitration
Glycosylation
Deacetylation
Acetylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTR

References

PMID: 8968737 by Leclerc D., et al. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.

PMID: 8968735 by Li Y.N., et al. Cloning, mapping and RNA analysis of the human methionine synthase gene.