MTHFD2 Antibodies

AND MTHFD2 ELISA kits, MTHFD2 Proteins

Many biological assays use antibodies to detect MTHFD2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTHFD2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTHFD2 antibodies...

We validate the specificity of these antibodies to MTHFD2 by testing them on tissues known to express MTHFD2 positively and negatively. Browse below to find the MTHFD2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTHFD2 Infographic by Boster Bio

All MTHFD2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

MTHFD2 (NM_006636) Human Recombinant Protein

$1062
Cat # PROTP13995
20 µg

Anti-MTHFD2 Antibody (C-term)

Human, Mouse

$299
Cat # M06465
50 µl

MTHFD2 (NM_006636) Human Over-expression Lysate

Human

$628
Cat # LS010797
100 µg

MTHFD2 Overview

Facts about Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial.

MTHFD2 3D structure. Source: alphafold

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Although its dehydrogenase activity is NAD-specific, it can also utilize NADP in a reduced efficiency. .

Gene Information

Human
Gene Name:	MTHFD2
Uniprot:	P13995
Entrez:	10797

Family

Belongs to:

tetrahydrofolate dehydrogenase/cyclohydrolase family

Alternative Names

bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase; methenyltetrahydrofolate cyclohydrolase; methylene tetrahydrofolate dehydrogenase (NAD+ dependent); methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2; mitochondrial; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase; NMDMC

Molecular Weight

Mass (kDA):
37.895 kDA

Genomic Context


Human

Location:	2p13.1
Sequence:	2; NC_000002.12 (74198563..74217565)

Subcellular Localizations

Mitochondrion.

Diseases

Malignant Neoplasms
5,10-methylenetetrahydrofolate Reductase Deficiency
Malignant Neoplasm Of Breast
Neoplasms
Mammary Neoplasms
Neoplasm Metastasis
Spina Bifida
Methylenetetrahydrofolate Reductase Deficiency
Friedreich Ataxia
Malnutrition
Hyperhomocysteinemia
Tumor Progression
Ataxia

Malignant Neoplasm Of Liver
Inflammatory Response
Malignant Neoplasm Of Urinary Bladder
Carcinogenesis
Congenital Heart Defects
Cardiovascular Diseases
Tumor Angiogenesis

Pathways

Dna Methylation
Methylation
Transport
Neural Tube Closure
Cell Proliferation
Mitosis
Inflammatory Response
Drug Resistance
Tube Closure
Cell Cycle

Telomere Maintenance
Cell Growth
Angiogenesis
Pathogenesis

PTMs

Methylation

Research Areas

Core ESC-Like Genes
Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTHFD2

References

PMID: 2587219 by Peri K.G., et al. Nucleotide sequence of the human NAD-dependent methylene tetrahydrofolate dehydrogenase-cyclohydrolase.

PMID: 16100107 by Christensen K.E., et al. Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase.