Myelin protein P0 Antibodies

Myelin protein P0 (MPZ)

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and drives myelin compaction.

.

Gene Information

Human
Gene Name:	MPZ
Uniprot:	P25189
Entrez:	4359

Family

Belongs to:
myelin P0 protein family

Alternative Names

Charcot-Marie-Tooth neuropathy 1B; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; HMSNIB; MPP; Myelin peripheral protein; myelin protein P0; myelin protein zeroDSS; P0

Molecular Weight

Mass (kDA):
27.555 kDA

Genomic Context

Human
Location:	1q23.3
Sequence:	1; NC_000001.11 (161303594..161309969, complement)

Tissue Specificity

Found only in peripheral nervous system Schwann cells.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.; [Isoform L-MPZ]: Myelin membrane; Single-pass type I membrane protein.

Diseases

• Charcot-marie-tooth Disease
• Peripheral Neuropathy
• Hereditary Motor And Sensory Neuropathies
• Inherited Neuropathy
• Dejerine-sottas Disease (disorder)
• Demyelinating Diseases
• Nervousness
• Polyneuropathy
• Sensory Neuropathy
• Tissue Adhesions
• Congenital Hypomyelinating Neuropathy

• Demyelination
• Weakness
• Atrophy
• Hereditary Liability To Pressure Palsies
• Muscular Atrophy
• Demyelinating Polyneuropathy

Pathways

• Myelination
• Pathogenesis
• Secretion
• Meiosis
• Localization
• Muscle Atrophy
• Transport
• Translation
• Myelin Maintenance
• Cell Proliferation
• Regeneration
• Corticosterone Secretion
• Aging

• Mitochondrial Fusion
• Cell Communication
• Schwann Cell Development
• Cell Development
• Glycosylation
• Cell Death
• Cell Adhesion

PTMs

• Phosphorylation
• Reduction

• Cleavage
• Glycosylation

• Methylation

Research Areas

• Neuronal Cell Markers
• Oligodendrocyte Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MPZ

Boster Bio - Best Uses Of The MPZ Marker

Boster Bio provides high-affinity primary antibodies which are optimized for WB applications when comparing MPZ marker markers. Their anti-PROM1 and CD235a antibodies can be used to identify proteins. Boster Bio also offers anti CD45, anti PROM1, anti Brca2, anti-Brca2, anti-CD45 and anti-PROM1 MPZ marker options.

Boster Bio offers high-affinity primary antibodies

A polyclonal antibodies' ability to bind specific antigens is an important aspect. Primary antibodies of high quality are defined by their specificity or affinity. Specificity measures how strong an antibody is to the targeted antigen. The stronger the antibody's affinity, it is more specific. Poor specificity, on the other hand, measures how strong it reacts to the unintended target antigen. A high-affinity primary antibody can be used for a variety of purposes, including detecting, purifying, and measuring antibodies.

Assays and experiments are only possible if primary and secondary antibodies work together. Their ability to bind antigens is the foundation for immunoassays such as Western Blotting, immunohistochemistry, and immunofluorescence. ELISA and flow cytometry are two other methods that can be used to determine the presence of certain cell types. Combining these two tools will allow researchers to test hypotheses more effectively and provide a more accurate diagnosis.

Optimizes antibodies for WB

The MPZ Marker, which is an essential component of Western Blotting, enhances the binding ability of monoclonal antibodies. Boster offers many conjugates that can be used to increase the binding affinity of monoclonal antibodies for Western Blotting applications. This unique feature allows researchers to customize antibody conjugates to meet specific applications. Boster MPZ Marker optimizes antibodies in WB by increasing their binding affinity and preventing cross reactivity.

Offers CD235a

The MPZ gene encodes a single nucleotide of the human genome. Its sequence is similar to that of human chromosomes. This means that it's highly relevant for studies involving the human immune system. It is a great candidate for mRNA sequence, a crucial technique for genetic mapping. In addition to its functional value, the MPZ gene is also associated with a wide range of diseases. It is worth investigating whether MPZ gene transcription is associated with cardiovascular disease.

Offers anti-PROM1 antibody

Boster Bio's Anti-Hu CD133 Purified ProM1 Monoclonal Antibody has been tested in WB, IHC, and reacts with Human. Blocking peptides can be purchased for further analysis. Prices for blocking proteins vary depending on the length and complexity of the immunogen. Boster Bio also provides negative and positive samples to validate its antibodies. The following are the benefits of purchasing an anti-PROM1 antibody from Boster Bio.

Boster Bio's Anti-PROM1 Antibody is available in five sizes. These sizes range from 5 ug/vial up to 100 ug/vial. This antibody reacts with Human, Mouse, and Rat. The antibody can also be used for immunofluorescence. The amount of blocking protein you require will affect the price. The PicobandTM catalog includes the Boster Bio Anti-PROM1 Antibody.

Boster Bio manufactures ELISA kit and research antibodies in addition to a wide range of anti-PROM1 antibodies. They are picogram sensitive and have been tested against 250 tissue samples. Boster Bio antibodies have been tested against a range of cell lines and are backed by the technical support of its distributor Sanbio. All BosterBio antibodies are valid for ELISA, WB and IHC.