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Multimerin-1 Antibodies
AND MMRN1 ELISA kits, Multimerin-1 Proteins
Many biological assays use antibodies to detect Multimerin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Multimerin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Multimerin-1 antibodies...
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MMRN1 Infographic by Boster Bio
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MMRN1 Overview
Facts about Multimerin-1.
Multimerin-1 (MMRN1)
Carrier protein for platelet (but not plasma) variable V/Va. Plays a role in the storage and stabilization of variable V in platelets.
Upon launch after platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may be the extracellular matrix or glue protein.
Gene Information
| Human | |
|---|---|
| Gene Name: | MMRN1 |
| Uniprot: | Q13201 |
| Entrez: | 22915 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ECMmultimerin; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN-4; EMILIN4GPIa*; Endothelial cell multimerin; glycoprotein Ia*; GPIA*; MMRN; multimerin 1; multimerin-1
Molecular Weight
Mass (kDA):
138.11 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q22.1 |
| Sequence: | 4; NC_000004.12 (89879511..89954629) |
Tissue Specificity
Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular tissues such as placenta, lung, and liver.
Subcellular Localizations
Secreted.
Diseases
- Parkinson Disease
- Malignant Neoplasms
- Tissue Adhesions
- Osteitis Deformans
- Infarction
- Persistant Generalized Lymphadenopathy
- Malignant Neoplasm Of Lung
- Progressive Supranuclear Palsy
- Carcinoma
- Carcinogenesis
- Ulcer
- Myocardial Infarction
- Vascular System Injuries
Pathways
- Coagulation
- Platelet Activation
- Cell Adhesion
- Dna Repair
- Endocytosis
- Chromosome Segregation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MMRN1
bosterbio.com/bosterbio-gene-info-cards/MMRN1
References
PMID: 7629143 by Hayward C.P.M., et al. The cDNA sequence of human endothelial cell multimerin. A unique protein with RGDS, coiled-coil, and epidermal growth factor-like domains and a carboxyl terminus similar to the globular domain of complement C1q and collagens type VIII and X.
PMID: 9798985 by Polgar J., et al. Platelet glycoprotein Ia* is the processed form of multimerin -- isolation and determination of N-terminal sequences of stored and released forms.