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Protein AF-9 Antibodies
AND MLLT3 ELISA kits, Protein AF-9 Proteins
Many biological assays use antibodies to detect Protein AF-9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein AF-9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein AF-9 antibodies...
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MLLT3 Overview
Facts about Protein AF-9.
Protein AF-9 (MLLT3)
Chromatin reader part of the super elongation complex (SEC), a complex needed to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948, PubMed:25417107, PubMed:27105114, PubMed:27545619). Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that's crotonylated (PubMed:25417107, PubMed:27105114, PubMed:27545619).
Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25417107, PubMed:27105114, PubMed:27545619). Recognizes and binds histone H3 crotonylated in'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylated in'Lys-18' (H3K18cr) (PubMed:27105114).
Gene Information
| Human | |
|---|---|
| Gene Name: | MLLT3 |
| Uniprot: | P42568 |
| Entrez: | 4300 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AF-9; AF9myeloid/lymphoid or mixed-lineage leukemia (trithorax (Drosophila) homolog);translocated to, 3; ALL1-fused gene from chromosome 9 protein; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog); translocatedto, 3; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 3; Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein; protein AF-9; YEATS domain-containing protein 3; YEATS3FLJ2035
Molecular Weight
Mass (kDA):
63.351 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p21.3 |
| Sequence: | 9; NC_000009.12 (20341669..20622499, complement) |
Subcellular Localizations
Nucleus. Chromosome. Colocalizes with acylated histone H3 (PubMed:25417107, PubMed:27105114). Colocalizes with histone H3 crotonylated at 'Lys-18' (H3K18cr) (PubMed:27105114).
Diseases
- Leukemia
- Chromosomal Translocation
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia
- Leukemogenesis
- Acute Leukemia
- Malignant Neoplasms
- Acute Lymphocytic Leukemia
- Cytogenetic Abnormality
- Cell Transformation, Neoplastic
- Acute Monocytic Leukemia
- Lymphoid Leukemia
Interacting Proteins
- AFF1
- AFF4
- ALKBH4
- APPBP2
- CBX8
- DOT1L
- FAM9A
Pathways
- Methylation
- Localization
- Pathogenesis
- Cell Cycle
- Transport
- Interphase
- Cell Proliferation
- Dna Methylation
- Gene Silencing
- Brain Development
- Regulation Of Gene Expression
- Nuclear Export
- Cell Cycle Arrest
PTMs
- Methylation
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MLLT3
bosterbio.com/bosterbio-gene-info-cards/MLLT3
References
PMID: 8506309 by Nakamura T., et al. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.
PMID: 10898795 by Huynh K.D., et al. BCoR, a novel corepressor involved in BCL-6 repression.