MKKS Antibodies

AND MKKS ELISA kits, MKKS Proteins

Many biological assays use antibodies to detect MKKS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MKKS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MKKS antibodies...

We validate the specificity of these antibodies to MKKS by testing them on tissues known to express MKKS positively and negatively. Browse below to find the MKKS antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MKKS Infographic by Boster Bio

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MKKS Overview

Facts about McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin.

MKKS 3D structure. Source: alphafold

McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin (MKKS)

Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (PubMed:20080638). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transfers vesicles to the cilia (PubMed:20080638).

May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (PubMed:28753627).

Gene Information

Human
Gene Name:	MKKS
Uniprot:	Q9NPJ1
Entrez:	8195

Family

Belongs to:

TCP-1 chaperonin family

Alternative Names

Bardet-Biedl syndrome 6 protein; BBS6MKS; HMCS; KMS; McKusick-Kaufman syndrome; McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin

Molecular Weight

Mass (kDA):
62.342 kDA

Genomic Context


Human

Location:	20p12.2
Sequence:	20; NC_000020.11 (10401009..10434222, complement)

Tissue Specificity

Widely expressed in adult and fetal tissues.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Nucleus. The majority of the protein resides within the pericentriolar material (PCM), a proteinaceous tube surrounding centrioles. During interphase, the protein is confined to the lateral surfaces of the PCM but during mitosis it relocalizes throughout the PCM and is found at the intercellular bridge. The MKSS protein is highly mobile and rapidly shuttles between the cytosol and centrosome.

Diseases

Bardet-biedl Syndrome
Obesity
Polydactyly
Kaufman-mckusick Syndrome
Retinitis Pigmentosa
Congenital Heart Defects
Diabetes Mellitus
Retinal Dystrophies
Retinal Diseases
Dystrophy
Heart Diseases

Congenital Heart Disease
Hypertensive Disease
Hereditary Diseases
Retinal Degeneration
Atresia
Blind Vision

Interacting Proteins

BBS12
BBS2

Pathways

Pathogenesis
Protein Folding
Rna Interference
Transport
Reproductive System Development
Cell Migration
Mitosis
Proteolysis
Immune Response
Dna Methylation
Localization
Cytokinesis
Methylation

Mismatch Repair
System Development
Axon Guidance
Cell Cycle
Interphase
Protein Processing
Secretion

PTMs

Methylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MKKS

References

PMID: 10802661 by Stone D.L., et al. Mutation of a gene encoding a putative chaperonin causes McKusick- Kaufman syndrome.

PMID: 15731008 by Kim J.C., et al. MKKS/BBS6, a divergent chaperonin-like protein linked to the obesity disorder Bardet-Biedl syndrome, is a novel centrosomal component required for cytokinesis.