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Facts about Macrophage migration inhibitory factor.
The expression of MIF in sites of inflammation suggests a role as mediator in regulating the use of macrophages in host defense. Counteracts the anti- inflammatory action of glucocorticoids.
Human | |
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Gene Name: | MIF |
Uniprot: | P14174 |
Entrez: | 4282 |
Belongs to: |
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MIF family |
EC 5.3.2.1; EC 5.3.3.12; GIFmacrophage migration inhibitory factor; GLIF; Glycosylation-inhibiting factor; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MIF; MMIF; Phenylpyruvate tautomerase
Mass (kDA):
12.476 kDA
Human | |
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Location: | 22q11.23 |
Sequence: | 22; NC_000022.11 (23894383..23895223) |
Secreted. Cytoplasm. Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
PMID: 2552447 by Weiser W.Y., et al. Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.
PMID: 8234256 by Mikayama T., et al. Molecular cloning and functional expression of a cDNA encoding glycosylation-inhibiting factor.
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