MGA Antibodies

MAX gene-associated protein (MGA)

Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core order and appears to regulate MYC-MAX target genes.

Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function triggered by heterodimerization with MAX.

Gene Information

Human
Gene Name:	MGA
Uniprot:	Q8IWI9
Entrez:	23269

Family

Belongs to:
No superfamily

Alternative Names

FLJ12634; KIAA0518; MAD5; MAX dimerization protein 5; MAX gene associated; MAX gene-associated protein; MXD5

Molecular Weight

Mass (kDA):
336.159 kDA

Genomic Context

Human
Location:	15q15.1
Sequence:	15; NC_000015.10 (41621225..41769943)

Subcellular Localizations

Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Carcinoma
• Iga Glomerulonephritis
• Kidney Diseases
• Hyperplasia
• Proteinuria Of Undiagnosed Cause
• Glomerulonephritis
• Neoplasm Metastasis

• Nephritis
• Hypertrophy
• Membranous Glomerulonephritis
• Nephrotic Syndrome
• Diabetes Mellitus
• 3-@methylglutaconic Aciduria, Type I

Interacting Proteins

• MAX

Pathways

• Estrus
• Ovulation
• Insemination
• Cell Proliferation
• Transport
• Secretion
• Excretion
• Parturition
• Luteolysis
• Fertilization
• Translation
• Cell Cycle

• Cell Death
• Cell Growth
• Cytolysis
• Dna Repair
• Innervation
• Programmed Cell Death
• Virulence

PTMs

• Oxidation
• Reduction
• Cleavage

• Methylation
• Glycosylation
• Acetylation

• Deglycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MGA

Best Uses Of The MGA Marker

You've come to the right spot if you're looking for monoclonal antibodies to the Macrophage Marker CD68. This section will provide details about high affinity primary antibodies as well as MGA markers. It also provides information about Steven Boster’s history. The MGA markers are extremely versatile and can be used in various research applications such as cancer research as well as autoimmune diseases and immunological disorders.

Anti-CD68 (Macrophage Marker) Monoclonal Antibody

The Mouse Monoclonal Antibody To CD68 is an excellent choice for detecting macrophages. It has been tested for use in IHC and has been tested on human as well as mouse and rat tissues. It is available in a 100-ug/vial dose and can be stored at temperatures ranging from -20°C to -80°C. The antibody will remain stable for at most 24 months.

CD68 is a key membrane protein found in many tissues. It is involved in phagocytosis within tissues, intracellular lysosomal metabolism, extracellular cell-cell interactions and interactions with pathogens. It is a member of the LAMP family. The murine ortholog is composed of 326 amino acids. They share an 80% amino acid sequence.

The antibodies were tested in flow cytometry, immunohistochemistry, and synovial membranes. In human synovial tissues, CD68+ cells were observed more frequently in samples with no subcutaneous fat. However, a higher percentage of cells expressed CD68+ in the greater saphenous vein. These findings suggest that anti-CD68 mAbs are highly effective for the detection of macrophages.

The immune cells of the tumor's microenvironment are expressed CD68. Gal1 has been discovered to regulate macrophages in glioma as well as melanomas. The tumor cells respond differently Gal1 neutralization than to knockdown of the gene. This antibody has also been proven to reduce the number of myeloid cells found in tumors.

The primary antibodies were dilute with blocking buffer and secondary antibodies were utilized to identify the lesion. The primary antibodies were used to detect the CD68 protein in areas of lesion and were HRP-conjugated to allow for immunostaining. The slides were cleaned and then processed in ethanol. The slides were then glued using Permount resin.

The Anti-CD68 antibody from Boster Bio recognizes CD14 as an molecule located on the surface of monocytes. It is an essential component of monocytesand is a type of phagocyte. The immune response to monocytes can regulate MSR expression which targets ligands that are used in antigen presentation. By inhibiting this receptor, it could help in preventing the onset of atherosclerosis.

High-affinity primary antibodies

Boster Bio is an antibody manufacturer that specializes in high-affinity polyclonal antibody and picogram sensitive ELISA kits. Boster Bio has over 12,000 antibodies, that have been validated quantitatively against 250 different tissues and untransfected cells. Boster Bio antibodies are available in various formats, including liquids, lyophilized and dilute.

This collection includes Fabs that were produced through a site-directed Mutagenesis technique employing the pcDNA3.4.TOPO vector. They are highly responsive to full-length PfCSP , and have a KD of 46.6 +4.7 nM. The Fabs included in the scFab structures were transiently expressed on cells derived from HEK293F. They were then purified by KappaSelect affinity chromatography.

The ELISA method is a powerful method of identifying specific analytes within the crude preparations. High-affinity antibodies bind specifically to the antigen and eliminate non-specific substances. This technique is known for its particularity and sensitivity. However, the procedure of evaluating the effectiveness of Boster Bio high-affinity primary antibodies is complicated and takes a long time. It's worth the extra effort and money.

Bioworld is a biotechnology company specializing in antibody purification and manufacture. Its headquarters are in Dublin, Ohio. The company is a major producer of phospho-antibodies. The company also provides ELISA kits. The company also provides contract services like the design of peptides, antibody optimization, and humanization. It has a long track record of making high-quality products for biomedical industry.

The human anti-B strain mAbs were not able to detect the majority of Pf sporozoites they did adhere to the new B strain with equal or greater affinity. This was possible despite the 10 percent difference in the sequence of HA. The researchers did not exclude the possibility of prior exposure to the B/Malaysia/2506/2004 Virus, even though serum titers from pre-vaccination were not significantly higher than the background levels. This study shows that OAS does not limit the reactivity to new strains of influenza, especially when memory B cells dominate the response.

After selecting, the MBP Linker-scFv was examined for specificity and cross-reactivity with IFN-g antigen. The antigen binding affinity was determined by ELISA and four different concentrations were tested. The measured values were compared to the values for other antigens and an affinity constant was calculated. The data showed that the MBP–Lk–scFv has a high affinity for the IFN–g antigen.

The MGA Marker has many benefits

MGAs are focused on the use of technology to improve risk assessments, distribution of products as well as acquisition costs and cost control. The introduction of the MGA Marker is one of the latest examples of this technology, and its introduction has a myriad of benefits for MGAs. Its full API allows seamless integration with existing MGA system, reducing the cost of acquisition and increasing efficiency. Its low cost and simple deployment make it a popular option for insurance companies and brokers.

MGAs have seen a rapid expansion in popularity, but paper providers are feeling the pinch and want to get control back over their underwriting. This is why the MGA Marker has risen to meet this demand and offer a simple method for paper companies to evaluate the performance of an MGA. The MGA Marker has many benefits that outweigh the risks. Whatever the benefits however, paper suppliers are required to deliver a high-quality product.

MGA incubators continue attracting experienced insurance professionals. The MGA model is a popular option for experienced insurance professionals seeking a less risky career path. The MGA Marker's recent success shows that senior talent is looking for unique opportunities. The US-focused Waypoint Underwriting Management was approved by Lloyd's to write accident and medical business for ArgoGlobalSyndicate 1200.

MGAs should be aware of the benefits of technology and how they can use it to remain relevant. Technology-driven solutions can help MGAs to be more efficient in delivering goods to the market. MGAs will be able to stay ahead in the marketplace and remain relevant in a lower value chain by incorporating technological innovations. Increased MGAs speed and competitiveness are two main advantages of the MGA Marker. They can also be used to bring fresh concepts to the market.

Steven Boster's history

Steve Boster, the late Steve, died Sunday, June 26, 2022. He was born in Joliet, IL and worked as a manager in retail sales for several decades. He was an active member of the U.S. Army and was also a member Concordia Hall in Staunton. His two daughters, Natosha and Crystal Boster, as well as 6 grandchildren and 4 brothers, are his survivors. His siblings are Sandra Blanton, Jack Boster, Lisa Milton, and Jonathan Boster. In addition to his mother, his father had several nieces and nephews who loved his.

Steve was devoted to his family above all other things. His family was his main focus, and his sons were his entire world. Steve was always the first one to call when his car had a problem at 2 a.m. Even when it was below freezing outside, he'd show up to help. He was generous to his family and friends and treated them as if they were family. The last part of Steve's story is fascinating! There's more that you can learn about this charismatic and talented man.