METTL1 Antibodies

tRNA (guanine-N(7)-)-methyltransferase (METTL1)

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. .

Gene Information

Human
Gene Name:	METTL1
Uniprot:	Q9UBP6
Entrez:	4234

Family

Belongs to:
class I-like SAM-binding methyltransferase superfamily

Alternative Names

C12orf1; D1075-like gene product; EC 2.1.1.33; FLJ95748; methyltransferase like 1; methyltransferase-like 1; Methyltransferase-like protein 1; TRM8; tRNA (guanine-N(7)-)-methyltransferase; tRNA(m7G46)-methyltransferase; YDL201w

Molecular Weight

Mass (kDA):
31.471 kDA

Genomic Context

Human
Location:	12q14.1
Sequence:	12; NC_000012.12 (57768471..57772105, complement)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Nucleus.

Diseases

• Cell Transformation, Neoplastic
• Malignant Neoplasms
• Lung Neoplasms
• Neoplasms
• Malignant Neoplasm Of Lung

Interacting Proteins

• WDR4

Pathways

• Methylation

PTMs

• Phosphorylation

• Cleavage

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/METTL1

The Best Uses Of The METTL1 Marker

If you're interested in the history of the METTL1 Marker and Steven Boster, this article is for you. We'll be discussing Steven Boster and the METTL1Marker's uses. And how scientists worldwide can benefit from the marker. The METTL1 molecule is an immunohistochemical mark derived from E. coli. This protein can be used by scientists around the world to determine the genetic makeup cells.

Steven Boster

Steve Boster (the creator of METTL1) has passed away. He died Sunday June 26, 2022. This article highlights some of his most noteworthy uses of the METTL1 marker. This list was compiled using many resources to help you remember Steve Boster. In addition to his writing, he left many other items behind. These are some of the most useful items he left behind. We hope you like them!

METTL1 Marker

METTL1 in LUAD tumors was associated wit a poor prognosis. METTL1 may be a diagnostic biomarker and therapeutic target for LUAD. Further studies were conducted to determine if the coding sequence from METTL1 could be sub-cloned in the pFLAGCMV-4 vector. METTL1 siRNAs are available as lentiviruses, AAVs, and oligo.

The METTL1 methylguanosine marker plays a pivotal part in regulating 7 methylguanosine(m7G), a crucial compound for cancer treatment. METTL1 had previously been found to be low expressed in CR–CC cells. However over-expression of the gene led to enhanced cytotoxic effects from cisplatin on CR–CC cancer cells. METTL1 was also shown to regulate miR149-3p.

Moreover, METTL1 is essential for mRNA translation. Depletion METTL1 caused a decrease in mRNA translation activity. However, reexpression wild-type METTL1 restored mRNA transcriptome efficiency in METTL1-deficient cells. METTL1 can promote mRNA transcriptase by relying on its m7G catalytic role.

METTL1 is a protein responsible for the m7G modification and tRNA/miRNA. Studies in the past were contradictory and controversial. METTL1 has been associated with poor outcomes in cancer patients. Recent research indicates that METTL1 has the potential to affect AKT/mTORC1 signaling, and carcinogenesis in various tissues.

METTL1 knockdown cells showed decreased tumor growth, smaller size and weight. In addition, METTL1 knockdown cells displayed decreased expression of Ki67 in the tumors and reduced proliferative activity of ESCC in vivo. METTL1-knockdown cells are useful in the study of ESCC. The exact role of METTL1 genes is still unknown.

The expression of a wide variety of genes can be affected by METTL1 inhibition. While METTL1 knockdown inhibits mRNA translation, it enhances the differentiation of hiPSCs into EBs and mesoderm. It promotes cell proliferation in human iPSCs as well as teratoma formation by mice. These results show that METTL1 can be knocked down to promote stem cell differentiation.

METTL1 knockdown can inhibit cell proliferation. Autophagy is also affected by METTL1 overexpression. This indicates that autophagy, which is essential for tumorigenesis, is a tumor suppressor in its early stages. In later stages, however, METTL1 could promote tumorigenesis. These findings require further investigation using more LUAD cells.

Its uses

The METTL1 gene encodes a guanine-N-methyltransferase, a protein similar to the S. cerevisiae YDL201w. Its product contains a conserved S-adenosylmethionine-binding motif. METTL1 is located on chromosome X. The METTL1 recombinant protein can be purchased as a blocking peptide.

Its history

Tumorigenesis has been linked to the METTL1 marker. Overexpression and knockdown of this protein can inhibit colony formation in A549 cell lines. Autophagy occurs when cells use lipids and proteins to maintain cellular homeostasis. While autophagy is considered a tumor-suppressing process during the initiation phase, it may also be responsible for tumorigenesis in established cancers. This study examined the role of METTL1 during autophagy using GEO2R, a gene expression analysis program. To evaluate the significance of METTL1 as a tumor suppressor, future studies need to verify these findings in more LUAD cell lines.

In addition to its role in tumorigenesis, METTL1 and m7G also play critical roles in cancer progression. Increased tumor growth is linked to higher levels of METTL1 (or m7G) in cancer cells. The progression of bladder, neck and head cancer is linked to the upregulation of these markers. Downregulation of METTL1 is also associated with increased tumorigenesis, a factor known to be associated with a variety of cancers.

The METTL1/WDR4 mRNA regulation complex regulates the m7G tRNA modifications process. METTL1 blocks HMGA2 and promotes cell cycle-related mRNAs. The METTL1/WDR4 combination plays important roles in stem cell differentiation and cancer. It is important not to forget that the METTL1/WDR4 complicated requires WDR4, a protein that is essential in METTL1 gene expression.

Although it is not clear what METTL1 does, there are important pathways that it regulates. Among them are cell proliferation and migration. In addition, METTL1 promotes miRNA processing. It also inhibits HMGA2, a crucial pathway for cancer development and poor survival. METTL1 has been linked with lung cancer progression. Further research is needed to determine the molecular mechanisms controlling its expression.

METTL1 (Metabolic enzyme) is a type of metabolic enzyme. In addition to regulating cellular growth, it regulates the production of several proteins. It is important to identify genes responsible for the development of cancer. In addition to mRNA, METTL1 can be detected using a variety of techniques, including gene-sequencing and RNA sequencing. In addition, METTL1 can be knocked down by transfection with si-METTL1 plasmids.