MELK Antibodies

AND MELK ELISA kits, MELK Proteins

Many biological assays use antibodies to detect MELK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MELK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MELK antibodies...

We validate the specificity of these antibodies to MELK by testing them on tissues known to express MELK positively and negatively. Browse below to find the MELK antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MELK Infographic by Boster Bio

All MELK Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MELK Antibody

13 Q&As

Human, Mouse, Rat

$360
Cat # A04038-1
100 µl

MELK Colorimetric Cell-Based ELISA

Human

ELISA

$480
Cat # EKC1811
1 kit, containing one 96-well plate and all necessary reagents

Anti-MELK (N449) Antibody

Human, Rat

IF, IHC, WB

$405
Cat # A04038
100ul

Anti-(Mouse) Melk Antibody (C-term)

Mouse

Flow Cytometry, WB

$299
Cat # M04038
80 µl

Anti-MELK Rabbit Monoclonal Antibody

Human

$370
Cat # M04038-1
100 μl/vial

MELK (NM_014791) Human Over-expression Lysate

Human

$628
Cat # LS009833
100 µg

Anti-MELK Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A04038-2
100 µg/vial

MELK Overview

Facts about Maternal embryonic leucine zipper kinase.

MELK 3D structure. Source: alphafold

Maternal embryonic leucine zipper kinase (MELK)

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1.

Acts as a regulator of cell cycle, especially by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis.

Gene Information

Human
Gene Name:	MELK
Uniprot:	Q14680
Entrez:	9833

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; hMELK; HPK38; KIAA0175pEg3 kinase; maternal embryonic leucine zipper kinase; MELK; PK38; Protein kinase PK38

Molecular Weight

Mass (kDA):
74.642 kDA

Genomic Context


Human

Location:	9p13.2
Sequence:	9; NC_000009.12 (36572862..36677683)

Tissue Specificity

Expressed in placenta, kidney, thymus, testis, ovary and intestine.

Subcellular Localizations

Cell membrane; Peripheral membrane protein.

Diseases

Malignant Neoplasms
Neoplasms
Brain Neoplasms
Glioblastoma
Malignant Paraganglionic Neoplasm
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Glioma
Colorectal Cancer
Cell Invasion
Glioblastoma Multiforme
Medulloblastoma

Colorectal Neoplasms
Leukemia
Neoplasm Metastasis
Anaplastic Astrocytoma
Neoplasm Invasiveness
Carcinoma
Mammary Neoplasms

Interacting Proteins

BCL2L14

Pathways

Cell Cycle
Cell Proliferation
Mitosis
Anaphase
Cytokinesis
Cell Division
Mrna Splicing
Translation
Mrna Processing
Interphase
Drug Resistance
Dna Replication
Rna Interference

Protein Phosphorylation
Cell Activation
Programmed Cell Death
T Cell Activation
Cell Cycle Arrest
Embryo Development
Gastrulation

PTMs

Phosphorylation

Cleavage

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MELK

References

PMID: 11802789 by Seong H.-A., et al. Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38).

PMID: 12400006 by Davezac N., et al. Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation.