Mediator of RNA polymerase II transcription subunit 12 (MED12)

Part of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator acts as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.

Mediator is recruited to promoters by direct interactions with regulatory proteins and functions as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of goals of the Wnt signaling pathway and SHH signaling pathway.