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Protein Mdm4 Antibodies
AND MDM4 ELISA kits, Protein Mdm4 Proteins
Many biological assays use antibodies to detect Protein Mdm4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein Mdm4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein Mdm4 antibodies...
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MDM4 Infographic by Boster Bio
All MDM4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1358
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1358
1 kit, containing one 96-well plate and all necessary reagents
MDM4 Overview
Facts about Protein Mdm4.
Protein Mdm4 (MDM4)
Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2.
Can reverse MDM2-targeted degradation of TP53 whilst maintaining suppression of TP53 transactivation and apoptotic functions. .
Gene Information
| Human | |
|---|---|
| Gene Name: | MDM4 |
| Uniprot: | O15151 |
| Entrez: | 4194 |
Family
| Belongs to: |
|---|
| MDM2/MDM4 family |
Alternative Names
DKFZp781B1423; double minute 4 homolog; Double minute 4 protein; double minute 4, human homolog of; p53-binding protein; HDMX; Mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog (mouse); MDM4 Regulator of P53; MDM4; Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse); Mdm4, transformed 3T3 cell double minute 4, p53 binding protein; MDM4-related protein 1; MDMX; MDMXMGC132766; mouse double minute 4, human homolog of; p53-binding protein; MRP1; p53-binding protein Mdm4; protein Mdm4; Protein Mdmx
Molecular Weight
Mass (kDA):
54.864 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q32.1 |
| Sequence: | 1; NC_000001.11 (204516377..204558120) |
Tissue Specificity
Expressed in all tissues tested with high levels in thymus.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Retinoblastoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Leukemia
- Lymphoma
- Brain Neoplasms
- Sarcoma
- Glioma
Interacting Proteins
- BCL2
- CD160
- CSNK1A1
- MDM2
- MKRN3
- RB1
- RNF115
- TP53
- UBE2D2
- USP7
Pathways
- Cell Cycle
- Cell Death
- Cell Cycle Arrest
- Cell Growth
- Cell Proliferation
- Localization
- Senescence
- Dna Repair
- Pathogenesis
- Induction Of Apoptosis
- Methylation
- Rna Interference
- Response To Stress
PTMs
- Phosphorylation
- Ubiquitination
- Methylation
Research Areas
- DNA Repair
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MDM4
bosterbio.com/bosterbio-gene-info-cards/MDM4
References
PMID: 9226370 by Shvarts A., et al. Isolation and identification of the human homolog of a new p53- binding protein, Mdmx.
PMID: 16266988 by Giglio S., et al. Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.