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MDM2 Antibodies
AND MDM2 ELISA kits, MDM2 Proteins
Many biological assays use antibodies to detect MDM2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MDM2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MDM2 antibodies...
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MDM2 Infographic by Boster Bio
All MDM2 Products
Product
Figures
Specificity
Applications
Price
Anti-MDM2 (Ab-166) Antibody
5 Citations 16 Q&As
Human, Monkey, Mouse, Rat
IF, IHC, WB
$360
Cat # A00054-1
100 µl
Cat # A00054-1
100 µl
Human, Mouse
ELISA
$480
Cat # EKC1357
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1357
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2086
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2086
1 kit, containing two 96-well plates and all necessary reagents
MDM2 Overview
Facts about E3 ubiquitin-protein ligase Mdm2.
E3 ubiquitin-protein ligase Mdm2 (MDM2)
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, resulting in its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
Also functions as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53.
Gene Information
| Human | |
|---|---|
| Gene Name: | MDM2 |
| Uniprot: | Q00987 |
| Entrez: | 4193 |
Family
| Belongs to: |
|---|
| MDM2/MDM4 family |
Alternative Names
ACTFS; HDM2; HDMX; MDM2 oncogene, E3 ubiquitin protein ligase; MDM2
Molecular Weight
Mass (kDA):
55.233 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q15 |
| Sequence: | 12; NC_000012.12 (68808149..68850686) |
Tissue Specificity
Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
Subcellular Localizations
Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 may be necessary to allow efficient nucleolar localization of both proteins. Colocalizes with RASSF1 isoform A in the nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Malignant Paraganglionic Neoplasm
- Retinoblastoma
- Sarcoma
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Leukemia
- Neoplasm Metastasis
- Carcinogenesis
- Liposarcoma
Pathways
- Cell Cycle
- Cell Cycle Arrest
- Cell Death
- Cell Proliferation
- Cell Growth
- Localization
- Pathogenesis
- Dna Repair
- Nuclear Export
- Senescence
- Induction Of Apoptosis
- Translation
- Methylation
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
- Acetylation
- Methylation
- Dephosphorylation
- Sumoylation
- Reduction
- Deacetylation
- Demethylation
Research Areas
- p53 Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MDM2
bosterbio.com/bosterbio-gene-info-cards/MDM2
References
PMID: 1614537 by Oliner J.D., et al. Amplification of a gene encoding a p53-associated protein in human sarcomas.
PMID: 8705862 by Sigalas I., et al. Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.
11 Publications of Boster MDM2 Antibodies & ELISA Kits
- PubMed ID: 10.7150/ijms.47360, Lipopolysaccharide Affects the Proliferation and Glucose Metabolism of Cervical ...
- PubMed ID: 10.3892/or.2015.4395, Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung c...
- PubMed ID: 10.1074/jbc.M115.658468, The Oncoprotein HBXIP Modulates the Feedback Loop of MDM2/p53 to Enhance the Gro...
- PubMed ID: 10.1016/j.bbadis.2016.12.009, Hotair facilitates hepatic stellate cells activation and fibrogenesis in the liv...
- PubMed ID: -, Jiang X,Yuan J,Dou Y,Zeng D, Xiao S.Lipopolysaccharide Affects the Proliferation...
- PubMed ID: 26676363, Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses th...
- PubMed ID: 26330014, Fra-1 is upregulated in gastric cancer tissues and affects the PI3K/Akt and p53 ...
- PubMed ID: 26549498, Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung c...
- PubMed ID: 26229107, The Oncoprotein HBXIP Modulates the Feedback Loop of MDM2/p53 to Enhance the Gro...
- PubMed ID: 25310288, Liao S, Xiao S, Zhu G, Zheng D, He J, Pei Z, Li G, Zhou Y. Oncol Rep. 2014 Dec;3...
- PubMed ID: 25651840, Xiao S, Zhou Y, Yi W, Luo G, Jiang B, Tian Q, Li Y, Xue M. Int J Oncol. 2015 Apr...
*More publications can be found for each product on its corresponding product page