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- Table of Contents
Facts about Matrilin-4.
Human | |
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Gene Name: | MATN4 |
Uniprot: | O95460 |
Entrez: | 8785 |
Belongs to: |
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No superfamily |
FLJ14417; MATN4; matrilin 4; Matrilin4; Matrilin-4
Mass (kDA):
68.487 kDA
Human | |
---|---|
Location: | 20q13.12 |
Sequence: | 20; NC_000020.11 (45293446..45308566, complement) |
Embryonic kidney, lung and placenta.
Secreted.
If you're looking for a high-quality antibody that's safe to use in your research, you've come to the right place. Boster Bio has primary antibodies that have been proven to be highly specific and affinity across multiple platforms. Boster bio also offers product credits to scientists who are among the first to review its products. Scientists all over the globe can get this recognition.
Boster Bio's reagents, antibodies and reagents have been thoroughly tested and validated for ELISA, WB and FC use. Boster Bio's antibodies will work in any type of test, whether you are testing human samples or mouse specimens. Boster Bio also produces a variety ELISA kits, buffers and lysates as well as control solutions and other reagents.
Boster's primary antibodies are well-known for their high affinity, no matter if you use ELISA and Western Blotting. The antibodies of the company have been extensively tested and cited by researchers for over 25 year, allowing them to be trusted in their efficacy. Researchers around the globe trust Boster’s antibodies. These antibodies have passed stringent quality control standards and have been vetted on Western Blotting, Immunohistochemistry, and ELISA.
The organization for antibody validation called GBSI has recently published guidelines defining fundamentals for standardized guidelines for antibody validation. This will be the starting point for implementing standardized guidelines for antibody validation. The GBSI emphasizes the importance of ensuring that antibodies are validated for their intended applications. App-based working group members will create appropriate validation standards and steps for their implementation during the 2017 meeting.
Furthermore, the antibody validation standards should be application-specific. Some antibodies may work well in one application, but fail in another. Scientists can benefit by the transparency of the process for their own in lab testing. It can also reduce the risk of inadvertently-validated antibodies. There are many ways to increase the validity of primary antibodies. A trusted antibody will increase the reproducibility for your research.
Traditional antibodies are often difficult to reproduce. Because they are not molecularly characterized, it is often difficult to reproduce the results. The challenge is made worse by the fact that antibodies are widely used. Researchers can use recombinant antibodies to gain standardized and reproducible products, which will reduce the need for validation.
If you are considering buying an antibody, be sure that it is validated on the major platforms for protein analysis. In addition to WB, you should look for IF/IC and ICC validation. IHC and ICC are the most common methods to determine the level of protein expression in a sample. However, WB is often a complementary assay. It can quantitatively assess protein levels in tissue sections to determine the specificity and specificity of an antigen. It should be noted, however, that a primary antibody may not recognize the same epitope in the two assays.
The ICC method uses fluorescent markers which are conjugated to antibodies. In this method, fluorescent labels are applied to the cell to identify the presence of the antigen. It is a great tool for determining if the target proteins is expressed and its location. WB staining techniques require the use of proper labeling and detection procedures to produce high signal–to–noise ratios.
WB immunoassays (IF/ICC) and WB immunoassays (WB) are complementary approaches. The latter is used to determine whether the primary antibody binds a target protein. For example, an antibody designed for ICC needs to be permeable to whole cells. The primary antibody binds to the protein in a different manner for IHC immunostaining and WB.
An ELISA test kit will work regardless of whether you are looking for IHC, WB, or ICC. The ELISA Kits can detect both recombinant or native proteins. This provides a more complete and reliable assay. The ELISA Kit also offers high levels of sensitivity, and specificity.
WB, IHC, IF and IHC are used primarily to detect proteins and antigens within cell culture. WB can be used to visualize protein distribution, while IHC requires cellular samples. ICC removes extracellular matter to study distribution of proteins, while IF uses cultured tissues. These immunoassays enable researchers to analyze tissue sections for glycan distribution and protein distribution.
Sino Biological, Inc. produces antibodies for WB, IHC, ICC, Immunofluorescence, and ELISA. The company offers more than 400 high-quality Immunofluorescence / IF / ICC antibodies. Sino Biological, Inc. employs a large array of antigens and rigorous testing to ensure that the highest quality products are available.
TransFix(r) is a patent-pending cellular stabilisation method. It extends the shelf life of blood samples while maintaining their immunophenotypic profiles for up to ten days. This product is beneficial in situations requiring storage and batching of samples. It also reduces the potential for biohazard exposure.
Steven Boster, who was a former student, was originally born in Joliet Illinois. He died Sunday, June 26, 20,22. He was the son of James and Evelyn Meier Boster. He was a manager in retail sales for many years. He was also a member of Concordia Hall of Staunton. His two daughters Natosha Peeck and Crystal Boster are his survivors. He also has six grandkids. His siblings, Jack and Tammy Boster, as well as his niece Lisa Milton, are also survived Boster.
Steve Boster valued his family. He loved singing in the lowest register in front of his family. He was also a big fan of auto racing, and was a great sports fan. He was always the first one to call if his car stopped working at two in the AM. He was also a regular at auto races, often showing up at two in the morning in sub-zero temperatures to fix it. He treated friends as family. As you can see Steven Boster's life was full of significant historical landmarks.
PMID: 9827539 by Wagener R., et al. Genomic organisation, alternative splicing and primary structure of human matrilin-4.
PMID: 15075323 by Mann H.H., et al. Interactions between the cartilage oligomeric matrix protein and matrilins. Implications for matrix assembly and the pathogenesis of chondrodysplasias.