MAPKAPK3 Antibodies

AND MAPKAPK3 ELISA kits, MAPKAPK3 Proteins

Many biological assays use antibodies to detect MAPKAPK3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPKAPK3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPKAPK3 antibodies...

We validate the specificity of these antibodies to MAPKAPK3 by testing them on tissues known to express MAPKAPK3 positively and negatively. Browse below to find the MAPKAPK3 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAPKAPK3 Infographic by Boster Bio

All MAPKAPK3 Products

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Product

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Specificity

Applications

Price

Anti-MAPK3 MAPKAPK3 Antibody

1 Citations 13 Q&As

Human, Mouse, Rat

IHC, WB

$360
Cat # A04510
100 µl

MAPK3 Colorimetric Cell-Based ELISA

Human, Mouse, Rat

ELISA

$480
Cat # EKC1835
1 kit, containing one 96-well plate and all necessary reagents

Human MAPKAPK3 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ16644
Starting from 20ug

Anti-MK3 Rabbit Monoclonal Antibody

Human

IP, WB

$370
Cat # M04510
100 μl/vial

MAPKAP Kinase 3 (MAPKAPK3) (NM_004635) Human Over-expression Lysate

Human

$628
Cat # LS007867
100 µg

MAPKAPK3 Overview

Facts about MAP kinase-activated protein kinase 3.

MAPKAPK3 3D structure. Source: alphafold

MAP kinase-activated protein kinase 3 (MAPKAPK3)

Following stress, it is phosphorylated and activated by MAP kinase p38- alpha/MAPK14, resulting in phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue.

MAPKAPK2 and MAPKAPK3, share the exact same function and substrate specificity, but MAPKAPK3 kinase activity and degree in protein expression are lower in comparison to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36.

Gene Information

Human
Gene Name:	MAPKAPK3
Uniprot:	Q16644
Entrez:	7867

Family

Belongs to:

protein kinase superfamily

Alternative Names

3PKEC 2.7.11.1; Chromosome 3p kinase; EC 2.7.11; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP33pK; MAPKAPK-3; mitogen-activated protein kinase-activated protein kinase 3

Molecular Weight

Mass (kDA):
42.987 kDA

Genomic Context


Human

Location:	3p21.2
Sequence:	3; NC_000003.12 (50611862..50649297)

Tissue Specificity

Widely expressed, with a higher expression level observed in heart and skeletal muscle. No expression in brain. Expressed in the retinal pigment epithelium (PubMed:26744326).

Subcellular Localizations

Nucleus. Cytoplasm. Predominantly located in the nucleus, when activated it translocates to the cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Colorectal Neoplasms
Inflammation
Encephalitis
Colorectal Cancer
Urticaria
Tissue Adhesions
Hiv Infections
Learning Disorders
Neoplasm Metastasis

Learning Disabilities
Hepatitis C, Chronic
Carcinoma
Severe Combined Immunodeficiency
Pituitary Diseases
Pheochromocytoma

Interacting Proteins

HSPB1
MAPK11
MAPK14

Pathways

Metabolic Process
Biological Regulation
Post-translational Protein Modification
Cognition
Transport
Cell Adhesion
Regulation Of Biological Process
Cell Proliferation
Developmental Process
Response To Stimulus
Proteolysis
Cellular Process
Primary Metabolic Process

Biosynthetic Process
Localization
Positive Regulation Of Cellular Process
Defense Response
Inflammatory Response
Regulation Of Cellular Process
Membrane Depolarization

PTMs

Phosphorylation

Acetylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPKAPK3

References

PMID: 8626550 by McLaughlin M.M., et al. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.

PMID: 8622688 by Sithanandam G., et al. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.

1 Publications of Boster MAPKAPK3 Antibodies & ELISA Kits

PubMed ID: -, Chumyam A. and Saengnil,K. 2021.Transient H2O2 induction by ClO2 fumigation alte...

*More publications can be found for each product on its corresponding product page