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MAP3K7 Antibodies
AND MAP3K7 ELISA kits, MAP3K7 Proteins
Many biological assays use antibodies to detect MAP3K7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K7 antibodies...
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MAP3K7 Infographic by Boster Bio
All MAP3K7 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # PB10006
100 μg/vial
Cat # PB10006
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01458
100 μl
Cat # M01458
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1347
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1347
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2311
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2311
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2566
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2566
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2567
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2567
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A01458T184-1
100ul
Cat # A01458T184-1
100ul
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A01458T187
100ul
Cat # A01458T187
100ul
Human, Mouse, Rat
IP, WB
$370
Cat # P01458
100 μl/vial
Cat # P01458
100 μl/vial
MAP3K7 Overview
Facts about Mitogen-activated protein kinase kinase kinase 7.
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an essential role in the cascades of cellular responses evoked by changes in the environment.
Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases such as MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAP3K7 |
| Uniprot: | O43318 |
| Entrez: | 6885 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.25; MAP3K7; MEKK7; mitogen-activated protein kinase kinase kinase 7; TAK1; TAK1/MAP3K7; TAK1TGF1a; TGF1a; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; Transforming growth factor-beta-activated kinase 1
Molecular Weight
Mass (kDA):
67.196 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q15 |
| Sequence: | 6; NC_000006.12 (90513579..90587072, complement) |
Tissue Specificity
Isoform 1A is the most abundant in ovary, skeletal muscle, spleen and blood mononuclear cells. Isoform 1B is highly expressed in brain, kidney and small intestine. Isoform 1C is the major form in prostate. Isoform 1D is the less abundant form.
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Although the majority of MAP3K7/TAK1 is found in the cytosol, when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2, it is also localized at the cell membrane.
Diseases
- Malignant Neoplasms
- Neoplasms
- Inflammation
- Malignant Tumor Of Colon
- Malignant Neoplasm Of Pancreas
- Cell Invasion
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Pancreatic Neoplasm
- Melanoma
- Carcinoma
- Myeloid Leukemia
- Retroviridae Infections
Interacting Proteins
- CDC37
- HSP90AA1
- MAP2K7
- MAPK8IP1
- NLK
- PPP6C
- STAT3
- TAB1
- TAB2
- TAB3
Pathways
- Immune Response
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Secretion
- Cell Adhesion
- Hair Follicle Morphogenesis
- Neural Tube Closure
- Hair Follicle Development
- Cell Migration
- Osteoblast Differentiation
- Aging
- Proteolysis
PTMs
- Phosphorylation
Research Areas
- Apoptosis
- Immunology
- Innate Immunity
- Phospho-Specific
- Protein Kinase
- Signal Transduction
- Wnt Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K7
bosterbio.com/bosterbio-gene-info-cards/MAP3K7
References
PMID: 9480845 by Sakurai H., et al. TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
PMID: 11118615 by Dempsey C.E., et al. Alternative splicing and gene structure of the transforming growth factor beta-activated kinase 1.