MAP3K3 Antibodies

AND MAP3K3 ELISA kits, MAP3K3 Proteins

Many biological assays use antibodies to detect MAP3K3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K3 antibodies...

We validate the specificity of these antibodies to MAP3K3 by testing them on tissues known to express MAP3K3 positively and negatively. Browse below to find the MAP3K3 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP3K3 Infographic by Boster Bio

All MAP3K3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MEKK3/MAP3K3 Antibody Picoband®

7 Q&As

Human

$370
Cat # PA1924
100 μg/vial

Anti-MEKK3/MAP3K3 Antibody Picoband®

1 Q&As

Mouse, Rat

IHC, WB

$370
Cat # PA1925
100 μg/vial

Anti-MEKK3 MAP3K3 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M03586
100 μl

Anti-MEKK3 MAP3K3 Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$405
Cat # A03586
100ul

MEKK3 (MAP3K3) (NM_002401) Human Over-expression Lysate

Human

$628
Cat # LS004215
100 µg

MAP3K3 Overview

Facts about Mitogen-activated protein kinase kinase kinase 3.

MAP3K3 3D structure. Source: alphafold

Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Gene Information

Human
Gene Name:	MAP3K3
Uniprot:	Q99759
Entrez:	4215

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11.25; MAP/ERK kinase kinase 3; MAP3K3; MAPK/ERK kinase kinase 3; MAPKKK3; MAPKKK3MEKK 3; MEK kinase 3; MEKK3; mitogen-activated protein kinase kinase kinase 3

Molecular Weight

Mass (kDA):
70.898 kDA

Genomic Context


Human

Location:	17q23.3
Sequence:	17; NC_000017.11 (63622209..63696305)

Diseases

Malignant Neoplasms
Inflammation
Tumor Angiogenesis
Neoplasms
Malignant Tumor Of Colon
Carcinoma
Mammary Neoplasms
Pathologic Neovascularization
Cell Transformation, Neoplastic
Tissue Adhesions
Malignant Neoplasm Of Breast
Ovarian Neoplasm

Psoriasis
Congenital Abnormality
Diabetes Mellitus
Cavernous Hemangioma Of Brain
Lymphopenia
Nervousness
Innate Immune Response

Interacting Proteins

MAP2K5
TRAF7
YWHAB
YWHAE
YWHAG

YWHAH
YWHAQ
YWHAZ

Pathways

Cell Proliferation
Angiogenesis
Cell Differentiation
Pathogenesis
Rna Interference
Cell Activation
T Cell Activation
Immune Response
Vasculogenesis
Cell Cycle Arrest
Cell Cycle
Oncogenesis
Mitosis

Cytokine Production
Secretion
Cell Migration
Regulation Of Signal Transduction
Tube Formation
Adaptive Immune Response
Keratinocyte Differentiation

PTMs

Phosphorylation
Ubiquitination

Cleavage
Methylation

Dephosphorylation

Research Areas

Angiogenesis
Cancer
Immunology
Innate Immunity
Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K3

References

PMID: 9006902 by Ellinger-Ziegelbauer H.C., et al. Direct activation of the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK) derivative.

PMID: 12761204 by Chun J., et al. Inhibition of mitogen-activated kinase kinase kinase 3 activity through phosphorylation by the serum- and glucocorticoid-induced kinase 1.