MAP3K2 Antibodies

AND MAP3K2 ELISA kits, MAP3K2 Proteins

Many biological assays use antibodies to detect MAP3K2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K2 antibodies...

We validate the specificity of these antibodies to MAP3K2 by testing them on tissues known to express MAP3K2 positively and negatively. Browse below to find the MAP3K2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP3K2 Infographic by Boster Bio

All MAP3K2 Products

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Product

Figures

Specificity

Applications

Price

Anti-MEKK2/MAP3K2 Antibody Picoband®

1 Citations 1 Q&As

Human, Mouse, Rat

$370
Cat # PA1499
100 μg/vial

Anti-MEKK2 MAP3K2 Rabbit Monoclonal Antibody

4 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M02354
100 μl

Anti-MEKK2 MAP3K2 Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IHC, ICC, WB

$405
Cat # A02354
100ul

Anti-MEKK2/MAP3K2 Antibody Picoband®

Human, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # A02354-1
100 μg/vial

MAP3K2 Overview

Facts about Mitogen-activated protein kinase kinase kinase 2.

MAP3K2 3D structure. Source: alphafold

Mitogen-activated protein kinase kinase kinase 2 (MAP3K2)

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity).

Plays a role in caveolae kiss-and-run dynamics. .

Gene Information

Human
Gene Name:	MAP3K2
Uniprot:	Q9Y2U5
Entrez:	10746

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11.25; MAP/ERK kinase kinase 2; MAP3K2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B; mitogen-activated protein kinase kinase kinase 2

Molecular Weight

Mass (kDA):
69.741 kDA

Genomic Context


Human

Location:	2q14.3
Sequence:	2; NC_000002.12 (127298668..127388465, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Upon EGF stimulation, translocates into the nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Prostatic Neoplasms
Inflammation
Malignant Neoplasm Of Prostate
Cell Transformation, Neoplastic
Hypertensive Disease
Cholangiocarcinoma
Fracture Of First Cervical Vertebra
Embryonal Carcinoma
Malignant Neoplasm Of Breast

Malignant Tumor Of Colon
Hepatitis B
Kidney Neoplasm
Lung Diseases
Hyperlipidemia
Ovarian Neoplasm
Rheumatoid Arthritis

Interacting Proteins

SFN
STUB1

Pathways

Cell Proliferation
Cytokine Production
Cell Activation
T Cell Activation
Immune Response
Cell Death
Cell Growth
Mast Cell Cytokine Production
Regulation Of Signal Transduction
Proteolysis
Adaptive Immune Response
Keratinocyte Differentiation
Sensitization

Translation
Response To Uv
Innate Immune Response
Cell Differentiation
Oncogenesis
Endoderm Formation
Hyperosmotic Response

PTMs

Phosphorylation
Ubiquitination

Nitration
Reduction

Methylation

Research Areas

Angiogenesis
Autophagy
Cancer
Mitophagy
Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K2

References

PMID: 10713157 by Cheng J., et al. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation.

PMID: 15075238 by Raviv Z., et al. MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.

1 Publications of Boster MAP3K2 Antibodies & ELISA Kits

PubMed ID: 25304384, Li Y, Zhang Z, Zhou X, Li L, Liu Q, Wang Z, Bai X, Zhao Y, Shi H, Zhang X, Ye L....

*More publications can be found for each product on its corresponding product page