MAP3K2 Antibodies

Mitogen-activated protein kinase kinase kinase 2 (MAP3K2)

Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity).

Plays a role in caveolae kiss-and-run dynamics. .

Gene Information

Human
Gene Name:	MAP3K2
Uniprot:	Q9Y2U5
Entrez:	10746

Family

Belongs to:
protein kinase superfamily

Alternative Names

EC 2.7.11.25; MAP/ERK kinase kinase 2; MAP3K2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B; mitogen-activated protein kinase kinase kinase 2

Molecular Weight

Mass (kDA):
69.741 kDA

Genomic Context

Human
Location:	2q14.3
Sequence:	2; NC_000002.12 (127298668..127388465, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Upon EGF stimulation, translocates into the nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Carcinoma
• Prostatic Neoplasms
• Inflammation
• Malignant Neoplasm Of Prostate
• Cell Transformation, Neoplastic
• Hypertensive Disease
• Cholangiocarcinoma
• Fracture Of First Cervical Vertebra
• Embryonal Carcinoma
• Malignant Neoplasm Of Breast

• Malignant Tumor Of Colon
• Hepatitis B
• Kidney Neoplasm
• Lung Diseases
• Hyperlipidemia
• Ovarian Neoplasm
• Rheumatoid Arthritis

Interacting Proteins

• SFN
• STUB1

Pathways

• Cell Proliferation
• Cytokine Production
• Cell Activation
• T Cell Activation
• Immune Response
• Cell Death
• Cell Growth
• Mast Cell Cytokine Production
• Regulation Of Signal Transduction
• Proteolysis
• Adaptive Immune Response
• Keratinocyte Differentiation
• Sensitization

• Translation
• Response To Uv
• Innate Immune Response
• Cell Differentiation
• Oncogenesis
• Endoderm Formation
• Hyperosmotic Response

PTMs

• Phosphorylation
• Ubiquitination

• Nitration
• Reduction

• Methylation

Research Areas

• Angiogenesis
• Autophagy
• Cancer
• Mitophagy
• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K2

Best Uses Of The MAP3K2 Marker

MAP3K2 marker is a protein kinase kinase kinase

MAP3K2 is a member the serine/threonine kinase protein kine family. It plays a critical role in the MAP kinase kinase signaling pathway. Activating MAP3K2 can have a variety of biological effects including inhibition of cell proliferation and progression.

In healthy individuals and patients with ischemic stroke, the serum levels of MAP3K2 were measured. It was found to be higher in patients suffering from ischemic stroke. There was a negative correlation with miR-379-5p. This may indicate that MAP3K2 is involved in the repair of damaged cartilage during OA.

The MAP3K2 MAP3K2 is a marker for protein kinase with high specificity. The antibody recognizes this protein. It activates MAP kinases, and acts as a transcriptional regulator. It is also associated NFKappa B signaling. MAP3K2 is an excellent marker of cancer and other diseases.

The MAP2K2 genome contains instructions for a protein phosphorylation enzym called MEK2. The MAP3K2 genome encodes a similar protein kinase – the MEK2 – which is part RAS/MAPK pathway. RAS/MAPK Signaling controls cell growth, division differentiation, movement and self-destruction.

Multiple types of cancer have been linked to the MAP3K2 gene. It regulates the expression of many genes in the brain. MAP3K2 regulates a wide range of pathways. MAP3K2 is an example of a pathway that inhibits IL-6. These findings suggest a role that MAP3K2 plays as a tumor suppressor.

MAP3K2 Marker is mapped to the activation domain of ERK5 and JNK pathways. It also controls the activity MAP2K5 & MAP2K7. It is important you understand how the signaling system works. As inhibition of MEK might improve the treatment of your pancreatitis.

The miR-372-3p link to p21 and HDAC4, as well as Wee1. MAP3K2 mRNA was compared with normal tissue and neighboring cell lines to determine its expression. Wee1 was not elevated in colon cancer tissue. A MAP3K2 mR-372-3p clone was found between HindIII & MulII.

The MEKK3 expression is a characteristic of MAP3K2 markers. Overexpression of MEKK3 is associated with poor prognosis in ESCC. MEKK3 cDNA was identified as an overexpressed gene in ESCCs. This marker offers valuable information about therapeutic options.

It is a protein kinase kinase kinase kinase kinase kinase kinase kinase kinase kinase kinase kinase kinase kinase kinase kinase

The MAP3K2 mark is a useful tool to biochemical and molecular biologists. This gene encodes one member of the serine/threonine-protein kinase kinase familia. It regulates the centrosomal location of the MAP4 and MAP2 proteins. It is also essential in the regulation of the G1/S Checkpoint. Boster Bio has developed antibodies to this marker.

Many cancer researchers have shown that MAP3K2 is a factor in the development of pancreatic ductal adenocarcinoma. These findings are consistent in previous studies. The marker has been linked to genes involved in cancer development. NR2F1–AS1 has been associated with osteosarcomas, ovarian and breast cancers, as well as endometrial, ovarian, and colorectal carcinomas.

Boster's MAP3K2 antibody offers high-affinity antibodies with excellent specificity, high affinity and high specificity. High-affinity antibodies from Boster are frequently cited in scientific literature. Researchers around the globe trust them. Boster's antibodies have been validated by Western blotting, Immunohistochemistry, and ELISA. They are also useful in determining the biological roles of MAP3K2 throughout a variety tissue, including the brain, liver and pancreas.

MAP3K2 is a protein in the body that regulates a process known as epithelial-mesenchymal transition (EMT). It helps to determine whether tumour cells are more likely to secrete insulin-like Growth Factor, which is a protein that is involved with immune system function. Further research can uncover how M2 or TAMs regulate EMT.

Using a radioimmunoprecipitation assay, we prepared cellular lysates containing equal amounts of protein. The protein concentrations were determined using a bicinchoninic acid protein assay kit. Equal amounts of protein were separated using 10% SDS-PAGE, and transferred onto PVDF membranes. These membranes were blocked with 5% nonfat milk for 1 h before incubating with primary antibodies. We used anti–E-cadherin (anti-N-cadherin), CD133, and Oct4 antibody.

The MAP3K pathway has important roles in regulating intracellular signaling. MAP3Ks are potential therapeutic targets in kidney disease and diabetes, and the targeting of MAP3K inhibitors may help treat some forms of chronic kidney disease. BRAF inhibitors (like the RAF1 inhibitors and MEKK inhibitors) can cause acute kidney injury and nephropathy.

The MAP3K2 antibody is extremely specific. The antibody is able to detect the protein within different subcellular compartments. The tracheal protein, which is predominantly nuclear, is a nuclear protein from the salivary gland. The reporter dye facilitates high-resolution analysis by flow cytometric techniques of the fluorescent signal. The MAP3K2 antibody also contains a reporter-dyed that allows for high resolution flow cytometry.

The RAF family members are potent therapeutic targets in multiple cancers. In prostate cancer, mutationally altered kinases are rare, but their wild-type counterparts are involved in progression of the disease. Phosphoproteomics, gene expression databases, and phosphateomics have identified 125 wild type kinases that are involved in metastatic ability in prostate cancer. Most of these kinases are RAF family members. RAF family members were the ones who drove bone metastasis. BRAF and MERTK are also involved in metastasis.