This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
MAP3K11 Antibodies
AND MAP3K11 ELISA kits, MAP3K11 Proteins
Many biological assays use antibodies to detect MAP3K11, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K11 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K11 antibodies...
Previous: CBLIF
Next: MLLT1
MAP3K11 Infographic by Boster Bio
All MAP3K11 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, WB
$360
Cat # P04412
100 µl
Cat # P04412
100 µl
MAP3K11 Overview
Facts about Mitogen-activated protein kinase kinase kinase 11.
Mitogen-activated protein kinase kinase kinase 11 (MAP3K11)
Activates the JUN N-terminal pathway.
Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7.Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAP3K11 |
| Uniprot: | Q16584 |
| Entrez: | 4296 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.25; MAP3K11; MEKK11; mitogen-activated protein kinase kinase kinase 11; Mixed lineage kinase 3; MLK3; MLK3MLK-3; PTK1; PTK1protein-tyrosine kinase PTK1; RHOE; SH3 domain-containing proline-rich kinase; SPRK; SPRKMGC17114; Src-homology 3 domain-containing proline-rich kinase
Molecular Weight
Mass (kDA):
92.688 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.1 |
| Sequence: | 11; NC_000011.10 (65597755..65614221, complement) |
Tissue Specificity
Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.
Subcellular Localizations
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Location is cell cycle dependent.
Diseases
- Malignant Neoplasms
- Neoplasms
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Cell Transformation, Neoplastic
- Cholangiocarcinoma
- Circling Gait
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Carcinogenesis
- Mammary Neoplasms
- Cytogenetic Abnormality
Interacting Proteins
- CDC42
- Map4k1
- NF2
Pathways
- Cell Proliferation
- Cell Cycle
- Localization
- Reverse Transcription
- Induction Of Apoptosis
- Cell Growth
- Pachytene
- Rna Interference
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K11
bosterbio.com/bosterbio-gene-info-cards/MAP3K11
References
PMID: 8195146 by Gallo K.A., et al. Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity.
PMID: 8183572 by Ing Y.L., et al. MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain.