MAP2 Antibodies

Microtubule-associated protein 2 (MAP2)

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

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Gene Information

Human
Gene Name:	MAP2
Uniprot:	P11137
Entrez:	4133

Family

Belongs to:
No superfamily

Alternative Names

DKFZp686I2148; MAP2; MAP-2; MAP2A; MAP2B; MAP2C; microtubule-associated protein 2

Molecular Weight

Mass (kDA):
199.526 kDA

Genomic Context

Human
Location:	2q34
Sequence:	2; NC_000002.12 (209424047..209734118)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection, dendrite.

Diseases

• Nervousness
• Alzheimer's Disease
• Ischemia
• Nerve Degeneration
• Neurodegenerative Disorders
• Neoplasms
• Brain Ischemia
• Brain Injuries
• Neuroblastoma
• Cerebral Ischemia
• Neurofibrillary Tangles
• Tissue Adhesions

• Epilepsy
• Neurotoxicity Syndromes
• Arterial Occlusion
• Infarction
• Cerebrovascular Accident
• Brain Neoplasms
• Occlusion, Middle Cerebral Artery

Interacting Proteins

• CBFB

Pathways

• Localization
• Cell Death
• Transport
• Neurogenesis
• Cell Cycle
• Pathogenesis
• Brain Development
• Cell Adhesion
• Cell Proliferation
• Cell Differentiation
• Regeneration
• Hyperphosphorylation
• Proteolysis

• Protein Phosphorylation
• Cell Division
• Neuroprotection
• Aging
• Translation
• Mitosis
• Innervation

PTMs

• Phosphorylation
• Dephosphorylation
• Cleavage
• Acetylation
• Reduction
• Biotinylation
• Oxidation
• Glycosylation
• Methylation

• Demethylation
• Ribosylation
• Ubiquitination
• Carboxylation
• Glutathionylation
• Carbamylation
• Glutamylation
• Deglycosylation
• Myristoylation

Research Areas

• Cell Biology
• Cellular Markers
• MAP Kinase Signaling
• Neuroscience
• Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP2

Boster Bio - Best Uses Of The MAP2 Marker

If you're using the Boster Bio Anti-MAP2 Antibody to identify MAP2 proteins in a specific sample or applying it to a species or species, an understanding of this protein can help you get the most accurate results. The Boster Bio MAP2 marker is an excellent tool that can simplify your work. There's even an troubleshooting guide.

Boster Bio Anti-MAP2 Antibody

The MAP2 marker is a 280-kD protein that is highly expressed in the dendrites of neurons and somata. The gene responsible for MAP2 has 19 exons. It is located on the genome segment 2q34-q35. Studies have shown that transgenic MAP2c protein are expressed in cell bodies and dendrites but their messenger RNA is restricted to the cell bodies. Boster Bio AntiMAP2 antibody reacts to MAP2 marker in human and mouse cells.

Boster Bio IHC protocol

The Boster Bio IHC protocol for the map2 marker is a step by step guide that explains the IHC procedure in detail. It provides recommended reagents and a guide for beginners and detailed information about sample preparation. The Boster Bio IHC guide also includes useful tips for troubleshooting as well as tools. For instance, the guide includes some possible errors and gives suggestions on how to fix and embed the sample.

BosterBio's anti-MAP2 antibody is a monoclonal mouse antibody which reacts with MAP2 both in IHC and IF. This antibody has been shown to work in several methods, including Western blot. It is recommended that the sample be fixed as soon as possible so that the antigens do NOT denature. The sample can be stained after it has been fixed.

IHC is a popular technique in many laboratories. It permits the visualization of cells and their tissue context. There are a variety of IHC methods for localizing antigens. However, the best method will be selected based on specimen preparation and the type of sample, as well as the sensitivity of the test. The quality of the tissue sample is critical for IHC.

Microtubule-associated protein 2 (MAP2) is a cytoskeleton protein abundant in the brain and plays a pivotal role in neuronal morphogenesis. It is found in both dendrites and axons. It is used to identify neuron formation. Reprogramming NG2 Glia can enable adult neurogenesis and functional recovery after spinal cord injury.

Boster Bio troubleshooting guides

There will be common issues in every experiment. Examples include the background is too high, or there are unexpected staining or weak fluorescence signals. While appropriate controls can eliminate many sources of error and are necessary for avoiding them, these issues are often not solved even if you follow the recommended flow protocols. If you are facing these issues it is recommended that you consult the troubleshooting guides of Boster Bio can help you overcome these issues and increase the effectiveness of your research.