MAP1B Antibodies

AND MAP1B ELISA kits, MAP1B Proteins

Many biological assays use antibodies to detect MAP1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP1B antibodies...

We validate the specificity of these antibodies to MAP1B by testing them on tissues known to express MAP1B positively and negatively. Browse below to find the MAP1B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP1B Infographic by Boster Bio

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Anti-MAP1B Antibody

Human, Mouse, Rat

IHC

$380
Cat # A01760
100ul

MAP1B Overview

Facts about Microtubule-associated protein 1B.

MAP1B 3D structure. Source: alphafold

Microtubule-associated protein 1B (MAP1B)

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension.

Possibly MAP1B binds to at least two tubulin subunits from the polymer, and this bridging of subunits may be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

Gene Information

Human
Gene Name:	MAP1B
Uniprot:	P46821
Entrez:	4131

Family

Belongs to:

MAP1 family

Alternative Names

DKFZp686E1099; DKFZp686F1345; FLJ38954; FUTSCH; MAP-1B; MAP5; microtubule-associated protein 1B

Molecular Weight

Mass (kDA):
270.634 kDA

Genomic Context


Human

Location:	5q13.2
Sequence:	5; NC_000005.10 (72107475..72209565)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine. Colocalizes with DAPK1 in the microtubules and cortical actin fibers.; [MAP1 light chain LC1]: Cytoplasm.

Diseases

Nervousness
Alzheimer's Disease
Neurodegenerative Disorders
Nerve Degeneration
Atrophy
Muscular Atrophy
Spinal Muscular Atrophy
Fragile X Syndrome
Neuroblastoma
Neoplasms
Neurofibrillary Tangles

Cerebrovascular Accident
Ischemia
Epilepsy
Giant Axonal Neuropathy 1
Dysplasia
Malignant Neoplasms

Interacting Proteins

GAN
KIRREL3
LRRK2
TP53

Pathways

Localization
Brain Development
Transport
Regeneration
Cell Death
Translation
Cell Differentiation
Pathogenesis
Neurogenesis
Hyperphosphorylation
Aging
Autophagy
Axon Extension

Axonogenesis
Protein Phosphorylation
System Development
Mitosis
Cell Growth
Cell Adhesion
Axon Guidance

PTMs

Phosphorylation
Dephosphorylation
Cleavage
Acetylation
Methylation
Nitrosylation

Biotinylation
Reduction
Glycosylation
Deacetylation
Phosphorothionation
Ubiquitination

Research Areas

Cell Biology
Cellular Markers
MAP Kinase Signaling
Neuronal Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP1B

References

PMID: 7806212 by Lien L.L., et al. Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15.

PMID: 12684070 by Dergunova L.V., et al. Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region.