MAMLD1 Antibodies

AND MAMLD1 ELISA kits, MAMLD1 Proteins

Many biological assays use antibodies to detect MAMLD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAMLD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAMLD1 antibodies...

We validate the specificity of these antibodies to MAMLD1 by testing them on tissues known to express MAMLD1 positively and negatively. Browse below to find the MAMLD1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAMLD1 Infographic by Boster Bio

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Chromosome X open reading frame 6 (MAMLD1) (NM_005491) Human Over-expression Lysate

Human

$960
Cat # LS010046
100 µg

MAMLD1 Overview

Facts about Mastermind-like domain-containing protein 1.

MAMLD1 3D structure. Source: alphafold

Mastermind-like domain-containing protein 1 (MAMLD1)

Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ.

Gene Information

Human
Gene Name:	MAMLD1
Uniprot:	Q13495
Entrez:	10046

Family

Belongs to:

mastermind family

Alternative Names

chromosome X open reading frame 6; CXorf6Protein CG1; F18CG1mastermind-like domain-containing protein 1; HYSP2; mastermind-like domain containing 1

Molecular Weight

Mass (kDA):
83.231 kDA

Genomic Context


Human

Location:	Xq28
Sequence:	X; NC_000023.11 (150361564..150514178)

Tissue Specificity

Expressed in fetal brain, fetal ovary and fetal testis. Expressed in adult brain, ovary, skin, testis, uterus. Highly expressed in skeletal muscle.

Subcellular Localizations

Nucleus. Punctate nuclear localization.

Diseases

Hypospadias
Disorders Of Sex Development
Neoplasms
46, Xy Disorders Of Sex Development
Congenital Abnormality
Cryptorchidism
Gonadal Dysgenesis
Leydig Cell Tumor
Mutation, Out-of-frame
Metabolic Acidosis
Aneuploidy
De Novo Mutation

Single Gene Defect
Infertility
Virilism
Pedal Edema
Hypoglycemia
Congenital Absence Of Adrenal Gland

Pathways

Sex Differentiation
Cell Proliferation
Sex Determination
Pathogenesis
Localization

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAMLD1

References

PMID: 8640223 by Laporte J., et al. A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast.

PMID: 18162467 by Fukami M., et al. Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.