Melanoma-associated antigen 6 (MAGEA6)

Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May improve ubiquitin ligase activity of TRIM28 and excite p53/TP53 ubiquitination by TRIM28.

Proposed to behave through recruitment and/or stabilization of this Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression.