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- Table of Contents
Facts about Mitotic spindle assembly checkpoint protein MAD1.
Has a role in the proper positioning of the septum. Required for anchoring MAD2L1 into the nuclear periphery.
Human | |
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Gene Name: | MAD1L1 |
Uniprot: | Q9Y6D9 |
Entrez: | 8379 |
Belongs to: |
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MAD1 family |
hMAD1; HsMAD1; MAD1 mitotic arrest deficient-like 1 (yeast); MAD1; MAD1L1; MAD1-like protein 1; MAD1yeast, homolog-like 1; Mitotic checkpoint MAD1 protein homolog; PIG9; Tax-binding protein 181; TP53I9; tumor protein p53 inducible protein 9; TXBP181; TXBP181MAD1 (mitotic arrest deficient, yeast, homolog)-like 1
Mass (kDA):
83.067 kDA
Human | |
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Location: | 7p22.3 |
Sequence: | 7; NC_000007.14 (1815795..2232945, complement) |
Expressed weakly at G0/G1 and highly at late S and G2/M phase.
Nucleus. Chromosome, centromere, kinetochore. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Detected at the nucleus envelope during interphase (PubMed:22351768). From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Detected at kinetochores during prometaphase (PubMed:22351768). Colocalizes with NEK2 at the kinetochore (PubMed:14978040). Colocalizes with IK at spindle p
PMID: 9546394 by Jin D.-Y., et al. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1.
PMID: 10198256 by Seeley T.W., et al. Phosphorylation of human MAD1 by the BUB1 kinase in vitro.