Core histone macro-H2A.1 Antibodies

AND MACROH2A1 ELISA kits, Core histone macro-H2A.1 Proteins

Many biological assays use antibodies to detect Core histone macro-H2A.1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Core histone macro-H2A.1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Core histone macro-H2A.1 antibodies...

We validate the specificity of these antibodies to Core histone macro-H2A.1 by testing them on tissues known to express MACROH2A1 positively and negatively. Browse below to find the MACROH2A1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MACROH2A1 Infographic by Boster Bio

All MACROH2A1 Products

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Specificity

Applications

Price

MACROH2A1 (NM_004893) Human Over-expression Lysate

Human

$628
Cat # LS009555
100 µg

Anti-H2AFY/MACROH2A1 Antibody Picoband®

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A04635-3
100 µg/vial

MACROH2A1 Overview

Facts about Core histone macro-H2A.1.

MACROH2A1 3D structure. Source: alphafold

Core histone macro-H2A.1 (MACROH2A1)

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes in which it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes compact and wrap DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template.

Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Gene Information

Human
Gene Name:	MACROH2A1
Uniprot:	O75367
Entrez:	9555

Family

Belongs to:

No superfamily

Alternative Names

Core histone macro-H2A.1

Molecular Weight

Mass (kDA):
39.617 kDA

Genomic Context


Human

Location:	5q31.1
Sequence:	5; NC_000005.10 (135334381..135401998, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus. Chromosome. Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Interacting Proteins

ATRX
ERBB2
ERICH2
MAX
TNKS

PTMs

Acetylation
Isopeptide bond

Methylation
Phosphoprotein

Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MACROH2A1

References

PMID: 9714746 by Lee Y., et al. Isolation of cDNA clones encoding human histone macroH2A1 subtypes.

PMID: 9653160 by Mao M., et al. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning.