LTBP1 Antibodies

AND LTBP1 ELISA kits, LTBP1 Proteins

Many biological assays use antibodies to detect LTBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LTBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LTBP1 antibodies...

We validate the specificity of these antibodies to LTBP1 by testing them on tissues known to express LTBP1 positively and negatively. Browse below to find the LTBP1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LTBP1 Infographic by Boster Bio

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Anti-LTBP1 Antibody

Human, Mouse, Rat

$405
Cat # A03224
100ul

LTBP1 Overview

Facts about Latent-transforming growth factor beta-binding protein 1.

LTBP1 3D structure. Source: alphafold

Latent-transforming growth factor beta-binding protein 1 (LTBP1)

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent condition during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates especially via disulfide bonds with the Latency-associated peptide (LAP), that's the regulatory chain of TGF-beta, also modulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403).

Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). .

Gene Information

Human
Gene Name:	LTBP1
Uniprot:	Q14766
Entrez:	4052

Family

Belongs to:

LTBP family

Alternative Names

Latent TGFbeta bp1; Latent TGF-beta bp1; latent transforming growth factor beta binding protein 1; latent-transforming growth factor beta-binding protein 1; LTBP1; LTBP-1; MGC163161; TGF-beta1-BP-1; Transforming growth factor beta-1-binding protein 1

Molecular Weight

Mass (kDA):
186.796 kDA

Genomic Context


Human

Location:	2p22.3
Sequence:	2; NC_000002.12 (32902129..33399509)

Tissue Specificity

Expressed in the aorta (at protein level) (PubMed:17293099). Isoform Long: Expressed in fibroblasts (PubMed:17293099).

Subcellular Localizations

Secreted. Secreted, extracellular space, extracellular matrix.

Diseases

Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Neoplasms
Fibrosis
Carcinoma
Mammary Neoplasms
Marfan Syndrome
Exfoliation Syndrome
Liver Cirrhosis
Arteriosclerosis
Hyperplasia
Tuberculosis
Malignant Neoplasm Of Breast

Diabetes Mellitus
Osteosarcoma
Urinary Stress Incontinence
Elastoid Degeneration
Pulmonary Emphysema
Dwarfism
Ovarian Neoplasm

Interacting Proteins

FBN1
TGFB1

Pathways

Secretion
Localization
Pathogenesis
Cell Proliferation
Lung Development
Gene Silencing
Proteolysis
Ossification
Reverse Transcription
Tissue Remodeling
Cell Growth
Muscle Cell Proliferation
Tube Formation

Mesenchymal Cell Proliferation
Chondrocyte Differentiation
Cell Motility
Cell Differentiation
Wound Healing
Transdifferentiation
Smooth Muscle Cell Proliferation

PTMs

Cleavage
Phosphorylation

Glycosylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LTBP1

References

PMID: 2350783 by Kanzaki T., et al. TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.

PMID: 8537398 by Olofsson A., et al. Efficient association of an amino-terminally extended form of human latent transforming growth factor-beta binding protein with the extracellular matrix.