Lymphotoxin-alpha Antibodies

Lymphotoxin-alpha (LTA)

Cytokine that in its own homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR.

Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. .

Gene Information

Human
Gene Name:	LTA
Uniprot:	P01374
Entrez:	4049

Family

Belongs to:
tumor necrosis factor family

Alternative Names

LT; LTA; LT-alpha; lymphotoxin alpha (TNF superfamily, member 1); Lymphotoxin alpha; Lymphotoxinalpha; Lymphotoxin-alpha; tnfb; TNF-beta; TNFBlymphotoxin-alpha; TNFSF1; TNFSF1B; TNFSF1TNF-beta; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1

Molecular Weight

Mass (kDA):
22.297 kDA

Genomic Context

Human
Location:	6p21.33
Sequence:	6; NC_000006.12 (31560550..31574324)

Subcellular Localizations

Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.

Diseases

• Inflammation
• Infective Disorder
• Malignant Neoplasms
• Inflammatory Response
• Systemic Infection
• Tissue Adhesions
• Myocardial Infarction
• Pneumonia
• Infarction
• Neoplasms
• Bacterial Infections
• Coronary Artery Disease
• Asthma

• Innate Immune Response
• Carcinoma
• Diabetes Mellitus
• Septic Shock
• Staphylococcal Infections
• Dysequilibrium Syndrome
• Hemorrhage

Pathways

• Secretion
• Pathogenesis
• Immune Response
• Platelet Aggregation
• Inflammatory Response
• Cytokine Production
• Virulence
• Localization
• Innate Immune Response
• Glycosylation
• Coagulation
• Autolysis
• Transport

• Cytokine Secretion
• Hypersensitivity
• Cell Division
• Cell Activation
• Macrophage Activation
• Platelet Activation
• Cell Death

PTMs

• Phosphorylation
• Glycosylation
• Cleavage
• Oxidation
• Acylation
• Ribosylation
• Acetylation
• Reduction
• Methylation

• Biotinylation
• Deglycosylation
• Hydroxylation
• Nitration
• Deacetylation
• Nitrosylation
• Carboxylation
• Ubiquitination
• Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LTA

Boster Bio Anti-TNF-Beta LTA Marker

Are you looking to purchase Boster Bio Anti-TNF-beta Bio Antibody Pioband(tm). This article will clarify the differences between ICC, IHC and the Boster Bio Anti–CD8 alpha/Cd8a antibody picoband(tm), and their best uses in cancer research and cell biology. Continue reading to find out more.

Boster Bio Anti-TNF-beta LTA Marker

Boster Bio AntiTNF-beto Marker for Mice is a mouse antibody which reacts with Human and Monkey. It can be stored at -20°C up to one year or frozen for up to six months. The kit contains 5 mg BSA and 0.05 mg thimerosal. For a particular length of immunogen, a blocking peptide can be purchased.

Flow cytometry is utilized for various applications in the fields of medicine and biology. The sample is made up of cells and particles. Boster offers monoclonal, polyclonal and high affinity primary antibodies. These antibodies are widely referenced and have been on the market for the last 25 years. It is reliable and precise in a variety of fields. If you are looking for an antibody with high affinity to detect TNF-beta in your research You can purchase the boster Bio Anti-TNF-beta LTA Marker.

Boster Bio Anti-CD8 alpha/Cd8a Antibody Picoband(tm)

Boster Bio's Anti CD8 alpha/Cd86a antibody Picoband(tm) tested using mouse, human and Rat samples It is a high-affinity primary antibody for CD8-positive cells. It binds to CK20. It is an extended protein encoded in the KRT20 gene. Keratins are proteins with high affinity to membranes. They preferentially bind to epithelial cell surface, and this protein is believed to play a part in endosomal flow. It is also implicated as a possible cause of Alzheimer's disease which is characterized by dysfunctional mitochondrial fusion and peroxisomal-fusion fusion. Boster also validates all its antibodies with positive and negative samples.

CD8 is an immunoreactive surface glycoprotein of cells that mediates cell-cell interactions. The antigen is assigned to 2p11.2 and acts as a coreceptor , recognizing the antigen expressed by APC or class I MHC molecules. The functional coreceptor's two beta and beta chains have significant similarities with the chains of immunoglobulin's variably light chains.

ICC

The LTA marker is a protein found in the blood of cancer patients in certain cases. It regulates the activity of macrophages. LTA can be expressed to monitor the effects that antigens exert on the body's immune systems. LTA has been utilized to study a variety of research objectives such as immuno system imaging and biomarker identification. LTA has also been shown to affect the human immune system's microenvironment via regulation of macrophages.

Early UCEC patients showed different expression of the LTA marker. It also correlated with common immune markers. GSE17025 data can be used in this regard. The LTA gene can be detected using immunoblotting or CCK8 analyses using RL95-2 cells. However, a prospective multicenter study is required to confirm the results. Furthermore, the data obtained from public databases are not validated in a clinical setting.

Toyota Lane Tracing Assist is a brand new technology that is available as part of the TSS 2.0 safety system. It is used in combination with Full Speed Range Dynamic Radar cruise control to avoid accidental Lane departures. Toyota Safety Sense 2.0 uses an forward-facing camera and radar system to guide the vehicle into the path. It does not replace the normal steering functions performed by the driver and could be unable to spot vehicles or lane markers. Safety is ultimately the responsibility of the driver, but it is important to be aware and aware of the environment.

IHC

In 1993, Steven Boster created the first ELISA kit that earned him the name "he who transforms science in the lavatory." This technology allows the same sample to include multiple antibodies and reagents. In the latter part of the 90s, Boster had developed a range of products for IHC and ELISA including hundreds of primary antibodies. He then developed a proprietary ELISA platform called PicoKine (tm) and developed proprietary trade secrets to deliver ultrahigh-sensitivity ELISA kits.

Immunofluorescence

The LTA marker is a multi-faceted and specific marker for the identification of macrophages and leukocytes. The antibody is a powerful tool in many types of diagnostic tests, including molecular diagnosis, immunohistochemistry, and cell biology. The antibody is able to react with a variety of cell types including granulocytes, lymphocytes, and granulocytes which share a common cell structure and function.

Indirect staining permits you to identify fluorescently labeled antibodies using unconjugated primary antibodies. Direct immunofluorescence staining reduces the chance of binding that is not specific by avoiding large anti-fluorophore complexes. Secondary antibodies are unable to penetrate cells. Direct staining can be extremely useful in the field of cancer research because it can detect multiple targets simultaneously.

Potentially effective in the treatment of inflammatory disorders.

Inflammation is a multifaceted pathophysiological and biological process that is closely connected to a number of different diseases. Treatment strategies can be greatly affected by the quantity and network pro-inflammatory factors that are involved in the development and onset of these diseases. While inflammation is a crucial component of the process itself it is also necessary to prevent tissue damage. The body has developed numerous ways to manage inflammation throughout evolution. Infections, immune system dysfunction, and other factors all influence the level and duration of inflammation in a given individual.

The regulation of inflammation is an important function that is played by the microRNA miR155. It has also been found to block the expression of eosinophilic chemicals. It was demonstrated in mice that mice that were miR-155 deficient were found to have a reduced number of Treg cells and decreased development. These studies suggest that miR155 has an important role in the process of inflammation and could be an effective treatment option for inflammation-related disorders.