LRP4 Antibodies

Low-density lipoprotein receptor-related protein 4 (LRP4)

Functions as a particular facilitator of SOST-mediated inhibition of Wnt signaling. Plays a vital role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle.

Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN- induced phosphorylation of MUSK, the kinase of the complex.

Gene Information

Human
Gene Name:	LRP4
Uniprot:	O75096
Entrez:	4038

Family

Belongs to:
LDLR family

Alternative Names

CLSS; KIAA0816; low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related protein 4; LRP10; LRP4; LRP-4; MEGF7LRP10; Multiple epidermal growth factor-like domains 7

Molecular Weight

Mass (kDA):
212.045 kDA

Genomic Context

Human
Location:	11p11.2
Sequence:	11; NC_000011.10 (46854715..46918550, complement)

Tissue Specificity

Expressed in bone; present in osteoblasts and osteocytes. No expression is observed in osteoclast. Expressed in several regions of the brain.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

• Myasthenias
• Myasthenia Gravis
• Myasthenic Syndromes, Congenital
• Syndactyly
• Fracture
• Osteoporosis
• Malignant Neoplasms
• Autoimmune Reaction
• Neuromuscular Diseases
• Neoplasms
• Weakness
• Malignant Neoplasm Of Lung

• Atherosclerosis
• Cattle Diseases
• Carcinoma
• Polysyndactyly
• Dysequilibrium Syndrome
• Congenital Abnormality
• Malignant Paraganglionic Neoplasm

Interacting Proteins

• SOST

Pathways

• Pathogenesis
• Endocytosis
• Limb Development
• Receptor-mediated Endocytosis
• Receptor Clustering
• Transport
• Reverse Transcription
• Exocytosis
• Osteoclast Differentiation
• Hair Follicle Development
• Cell Migration
• Proteolysis
• Immune Response

• Mesoderm Formation
• Muscle Contraction
• Ossification
• Cell Differentiation
• Bone Development
• Cell Communication
• Segmentation

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRP4

Boster Bio Anti-LRP4 Marker

If you want to get the most out your Boster Bio Anti LRP4Marker, then continue reading. We'll discuss its uses and benefits. You will also learn how to submit your results to earn product credits. These benefits are applicable to scientists all over the world. Why would anyone want this marker? Here are some reasons. These are only a few of many uses for the marker.

Boster Bio Anti-LRP4 Marker

A Boster Bio Anti-LRP4 Markers is an excellent way to detect biomarkers in cancer, development, neurosciences, and inflammation. This anti LRP4 antibody reacts well with human, mouse and rat tissues. Scientists may submit samples of their research and receive credit. All Boster Bio scientists can receive credit by submitting the findings to their company. You can find their products at tebu.bio.

Applications

The present invention uses a LRP4 protein to aid in cell biology, biochemical analysis, and genetic analysis. It is produced by gene recombination and is obtained from the dissolved product. The known methods of purifying the target polypeptide are salting out and distillation as well as gel electrophoresis. The method used to purify the Lrp4 polypeptide will vary according to the target cell type and species.

The gene encoding Lrp4 is found in dopaminergic neuron progenitor cells. Lrp4 is thought to regulate both neuron differentiation and progenitor cells proliferation. To manipulate these processes, substances that inhibit Lrp4 may be used. These substances could include antisense nucleic acid, ribozymes and small interferingRNA.

LRP4 genes have many other functions. It has been demonstrated to be essential in the diagnosis Cenani Lenz Syndrome. LRP4 causes limb malformations according to a genetic analysis. LRP4 is also involved with limb formation. These studies have revealed that LRP4 mutations may lead to altered binding to sclerostin.

The Lrp4 gene was found to be highly expressed by dopaminergic neuron-progenitor cells. Anti-Lrp4 antibodies are believed to be an effective method of isolating these cells. These anti–Lrp4 antibodies are very effective in isolating dopaminergic progenitor neurons in culture. Lrp4 can be used to identify regenerative disorders in mice and is effective in determining dopaminergic neuron precursor cells' source.

Benefits

LRP4 is a molecule produced by the star-shaped brain cells called astrocytes. This molecule is vital for maintaining healthy levels a particular brain chemical called glutamate. This chemical is transmitted from one neuron in the brain to the other, allowing learning and memory. Astrocytos may be able treat brain injury or damage by controlling this communication. LRP4 can help maintain healthy levels glutamate and may also protect against seizures.

LRP4 is a promising biomarker in the diagnosis of lung cancer. The LRP4 gene is expressed in many tissues and organs, including the lungs and other body fluids. It is also critical for regulating the immune reaction to infectious diseases. It plays an important role in tissue homeostasis and in the elimination of apoptotic cell. This marker may be helpful in identifying disease-causing agents and improving the treatment process.

LRP4 protein is vital for maintaining the neuromuscular joint. Many diseases can affect this complex process. Myasthenia gravis patients often have antibodies to LRP4 protein. However, blood tests that test for this protein won't reveal a clear diagnosis. It plays a critical role in muscle development and maintenance. Therefore, it is crucial for diagnosing the disease. It is essential for the maintenance and formation of the neuromuscular intersection.

Despite the many potential benefits of LRP4 as a bone health marker, there are some major drawbacks. In the absence of a functional Lrp4 genetic, LRP4 protein is unable to function properly and cannot regulate sclerostin. This is a crucial signaling molecule for bone mass regulation. While the Lrp4 gene is not necessary for osteoporosis to form, activating it can help.

LRP regulates multiple signaling pathways, and modulates the expression target genes. LRP mutations are not likely to cause a distinct phenotype. However they will display an enlarged Kupffer cell line. This mutation has many implications in the development of CNS. It can lead to perinatal deaths. It can also cause severe olfactory disorders.

Lrp4 promotes bone growth, in addition to all these other benefits. Lrp4 deficiency can also cause inhibition of the activity kappa–b gene. Deficiency Lrp4 leads to increased SC proliferation. Although this decrease in Lrp4 does not reduce SC survival after nerve injury, it may increase the rate of demyelination and proliferation of mSCs, which may promote bone regeneration.

Lrp4 may also be beneficial for neuronal survival and axon growth. For example, overexpression of Lrp4 in mice has been associated with axon regeneration, and may therefore be a beneficial approach to regenerating motor neurons. This study found that Lrp4 is more effective in inhibiting the progression and development of axons in mice, which is good for nerve regeneration.