LRMP Antibodies

AND LRMP ELISA kits, LRMP Proteins

Many biological assays use antibodies to detect LRMP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRMP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRMP antibodies...

We validate the specificity of these antibodies to LRMP by testing them on tissues known to express LRMP positively and negatively. Browse below to find the LRMP antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LRMP Infographic by Boster Bio

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LRMP Overview

Facts about Lymphoid-restricted membrane protein.

LRMP 3D structure. Source: alphafold

Lymphoid-restricted membrane protein (LRMP)

Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent way. May play a role in taste signal transduction through ITPR3.

May play a role during fertilization in pronucleus congression and fusion. .

Gene Information

Human
Gene Name:	LRMP
Uniprot:	Q12912
Entrez:	4033

Family

Belongs to:

LRMP family

Alternative Names

Jaw1; JAW1Protein Jaw1; LRMP; lymphoid-restricted membrane protein

Molecular Weight

Mass (kDA):
62.122 kDA

Genomic Context


Human

Location:	12p12.1
Sequence:	12; NC_000012.12 (25052228..25108335)

Tissue Specificity

Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles.

Subcellular Localizations

[Processed lymphoid-restricted membrane protein]: Cytoplasm.; Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Membrane; Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Colocalized with ITPR3 on the endoplasmic reticulum membrane.

Diseases

Neoplasms
Adenoma
Malignant Neoplasms
Lung Neoplasms
Lung Adenoma
Cell Transformation, Neoplastic
Lymphoma
Adenocarcinoma
Diffuse Large B-cell Lymphoma
Malignant Neoplasm Of Lung
B-cell Lymphomas
Leukemia
Myeloid Leukemia

Diabetes Mellitus
Diabetes Mellitus, Insulin-dependent
Adenocarcinoma Of Lung (disorder)
Burkitt Lymphoma
Neoplasm Metastasis
Malignant Tumor Of Colon
Carcinoma

Pathways

Pronuclear Migration
Localization
Translation
Vesicle Targeting
Acute Inflammatory Response
Cell Proliferation
Induction Of Apoptosis
Mitosis
Fertilization
Dna Demethylation
Dna Methylation
Cytokinesis

Inflammatory Response
Demethylation
Methylation
Cell Cycle
T Cell Proliferation
Post-translational Protein Modification
Cell Growth

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRMP

References

PMID: 8021504 by Behrens T.W., et al. Jaw1, a lymphoid-restricted membrane protein localized to the endoplasmic reticulum.

PMID: 16739114 by Tedoldi S., et al. Jaw1/LRMP, a germinal centre-associated marker for the immunohistological study of B-cell lymphomas.