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LRAT Antibodies
AND LRAT ELISA kits, LRAT Proteins
Many biological assays use antibodies to detect LRAT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LRAT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LRAT antibodies...
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LRAT Overview
Facts about Lecithin retinol acyltransferase.
Lecithin retinol acyltransferase (LRAT)
Transfers the acyl group from the sn-1 position of phosphatidylcholine into all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A.
LRAT plays a crucial role in vision. It offers the all-trans retinyl ester substrates for the isomerohydrolase which procedures the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments.
Gene Information
| Human | |
|---|---|
| Gene Name: | LRAT |
| Uniprot: | O95237 |
| Entrez: | 9227 |
Family
| Belongs to: |
|---|
| H-rev107 family |
Alternative Names
EC 2.3.1.135; LCA14; lecithin retinol acyltransferase (phosphatidylcholine--retinolO-acyltransferase); lecithin retinol acyltransferase; MGC33103; Phosphatidylcholine--retinol O-acyltransferase
Molecular Weight
Mass (kDA):
25.703 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q32.1 |
| Sequence: | 4; NC_000004.12 (154740841..154753120) |
Tissue Specificity
Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed in retinal pigment epithelium and liver, and barely in the brain.
Subcellular Localizations
Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum. Endosome, multivesicular body. Cytoplasm, perinuclear region. Present in the rough endoplasmic reticulum and multivesicular body in hepatic stellate cells. Present in the rough endoplasmic reticulum and perinuclear region in endothelial cells (By similarity).
Diseases
- Vitamin A Deficiency
- Leber Congenital Amaurosis
- Amaurosis
- Malignant Neoplasms
- Blind Vision
- Neoplasms
- Retinal Dystrophies
- Retinal Degeneration
- Carcinoma
- Dystrophy
- Retinitis Pigmentosa
- Carcinogenesis
Pathways
- Transport
- Regeneration
- Localization
- Phototransduction
- Pathogenesis
- Hatching
- Lung Development
- Retinol Transport
- Phagocytosis
- Meiosis
- Oogenesis
- Protein Palmitoylation
- Aging
PTMs
- Cleavage
- Palmitoylation
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LRAT
bosterbio.com/bosterbio-gene-info-cards/LRAT
References
PMID: 9920938 by Ruiz A., et al. Molecular and biochemical characterization of lecithin retinol acyltransferase.
PMID: 15474300 by Zolfaghari R., et al. Cloning, gene organization and identification of an alternative splicing process in lecithin:retinol acyltransferase cDNA from human liver.