Leupaxin Antibodies

AND LPXN ELISA kits, Leupaxin Proteins

Many biological assays use antibodies to detect Leupaxin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Leupaxin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Leupaxin antibodies...

We validate the specificity of these antibodies to Leupaxin by testing them on tissues known to express LPXN positively and negatively. Browse below to find the LPXN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LPXN Infographic by Boster Bio

All LPXN Products

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Anti-Leupaxin/LPXN Antibody Picoband®

5 Q&As

Human, Mouse

Flow Cytometry, WB

$370
Cat # PA2195
100 μg/vial

Anti-LPXN Antibody Picoband®

Human, Mouse

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A06581
100 µg/vial

LPXN Overview

Facts about Leupaxin.

LPXN 3D structure. Source: alphafold

Leupaxin (LPXN)

Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events.

Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a crucial role as an adapter protein in the creation of the adhesion zone in osteoclasts.

Gene Information

Human
Gene Name:	LPXN
Uniprot:	O60711
Entrez:	9404

Family

Belongs to:

paxillin family

Alternative Names

LDLP; LDPL; leupaxin

Molecular Weight

Mass (kDA):
43.332 kDA

Genomic Context


Human

Location:	11q12.1
Sequence:	11; NC_000011.10 (58526871..58578239, complement)

Tissue Specificity

Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is directly linked to PCa progression.

Subcellular Localizations

Cytoplasm. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin.