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Facts about Lipoprotein lipase.
The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). .
Human | |
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Gene Name: | LPL |
Uniprot: | P06858 |
Entrez: | 4023 |
Belongs to: |
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AB hydrolase superfamily |
EC 3.1.1; HDLCQ11; LIPD; LIPDEC 3.1.1.34; Lipoprotein Lipase; LPL
Mass (kDA):
53.162 kDA
Human | |
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Location: | 8p21.3 |
Sequence: | 8; NC_000008.11 (19939253..19967259) |
Cell membrane; Peripheral membrane protein; Extracellular side. Secreted. Secreted, extracellular space, extracellular matrix. Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity).
The LPL marker can be used for many purposes. Based on your objectives as well as your audience and brand, you could use the marker to tell stories and market your brand. Here are some of the most effective ways to utilize it:
The LPL marker has been shown to have a proatherogenic effect in an atherosclerosis mouse model. It is believed to promote the formation of foam cells and oxidation of LDL. This could explain why it is so crucial in atherosclerosis. The LPL marker has a myriad of uses. Let's take a look at some of them. These are the most popular uses of LPL.
PMID: 3823907 by Wion K.L., et al. Human lipoprotein lipase complementary DNA sequence.
PMID: 2701938 by Gotoda T., et al. Nucleotide sequence of human cDNA coding for a lipoprotein lipase (LPL) cloned from placental cDNA library.
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