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- Table of Contents
Facts about Leucyl-cystinyl aminopeptidase.
May be involved in the inactivation of neuronal peptides from the brain. Cleaves Met-enkephalin and dynorphin.
Human | |
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Gene Name: | LNPEP |
Uniprot: | Q9UIQ6 |
Entrez: | 4012 |
Belongs to: |
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peptidase M1 family |
angiotensin IV receptor; AT (4) receptor; CAP; Cystinyl aminopeptidase; EC 3.4.11; EC 3.4.11.3; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; leucyl/cystinyl aminopeptidase; Leucylcystinyl Aminopeptidase; Leucyl-cystinyl Aminopeptidase; LNPEP; Otase; Oxytocinase; Placental leucine aminopeptidase; PLAP; P-LAP; P-LAPinsulin-regulated aminopeptidase; Vasopressinase
Mass (kDA):
117.349 kDA
Human | |
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Location: | 5q15 |
Sequence: | 5; NC_000005.10 (96934859..97037513) |
Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
Cell membrane; Single-pass type II membrane protein. In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.; [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
Steven Boster can be read more about his work, background, family and life. This bio also includes information about the LNPEP marker as well as the various ways it is used. This article has information that will help you if you are interested in a career working in biometrics. It includes information about Steven Boster's history and family. You can also find out more about LNPEP marker and how they could benefit your business.
Steven Boster has been working on new products in immunohistochemistry for over a decade. He has been responsible for the creation of hundreds of primary antibody products and has also become China's largest catalog company for antibodies. His products include the PicoKine(tm) highly sensitive ELISA kits.
Steve Boster was a Joliet, IL native. He was the son of James Boster and Evelyn Meier. He was a Concordia Hall alumnus and worked in retail sales for many, many years. His family includes Crystal Boster (nee Natosha) and Crystal Peck (daughter), 6 grandchildren and 4 brothers, Jack Boster and Sandra Blanton. His nieces as well as nephews also survived him.
The LNPEP protein is produced by the LNPEP genetic. It can be quickly identified using the LNPEP marker. This gene is involved both in physiological and pathological conditions. Researchers can quickly identify variants of gene variants using this marker. This marker could be useful in future genetic studies of LNPEP gene. Here are the LNPEP markers results.
LNPEP can be found in the membrane's integral glycoproteins. It co-segregates in insulin-responsive cells with the GLUT4 transporter. It is responsible to catalyze the conversion from angiotensinogen (angiotensin III) to angiotensinogen. It is also expressed in the brain and has a positive influence on blood flow, synaptogenesis, and long-term potentiation.
The function of the ERAP2 gene is similar to that found in LNPEP. This gene is involved both in the conversion of AngII into AngIII and in preeclampsia as well as in autoimmune diseases. The gene is also associated with several diseases via RAS. ERAP2 is a functional protein. It also has a balanced polymorphism in the SNP rs2248374.
PMID: 8550619 by Rogi T., et al. Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family.
PMID: 9177475 by Laustsen P.G., et al. The complete amino acid sequence of human placental oxytocinase.