This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
LNPEP Antibodies
AND LNPEP ELISA kits, LNPEP Proteins
Many biological assays use antibodies to detect LNPEP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LNPEP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LNPEP antibodies...
Previous: CBLIF
Next: VWA5A
LNPEP Infographic by Boster Bio
All LNPEP Products
Product
Figures
Specificity
Applications
Price
Human
$960
Cat # LS004012
100 µg
Cat # LS004012
100 µg
LNPEP Overview
Facts about Leucyl-cystinyl aminopeptidase.
Leucyl-cystinyl aminopeptidase (LNPEP)
Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy.
May be involved in the inactivation of neuronal peptides from the brain. Cleaves Met-enkephalin and dynorphin.
Gene Information
| Human | |
|---|---|
| Gene Name: | LNPEP |
| Uniprot: | Q9UIQ6 |
| Entrez: | 4012 |
Family
| Belongs to: |
|---|
| peptidase M1 family |
Alternative Names
angiotensin IV receptor; AT (4) receptor; CAP; Cystinyl aminopeptidase; EC 3.4.11; EC 3.4.11.3; Insulin-regulated membrane aminopeptidase; Insulin-responsive aminopeptidase; IRAP; leucyl/cystinyl aminopeptidase; Leucylcystinyl Aminopeptidase; Leucyl-cystinyl Aminopeptidase; LNPEP; Otase; Oxytocinase; Placental leucine aminopeptidase; PLAP; P-LAP; P-LAPinsulin-regulated aminopeptidase; Vasopressinase
Molecular Weight
Mass (kDA):
117.349 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q15 |
| Sequence: | 5; NC_000005.10 (96934859..97037513) |
Tissue Specificity
Highly expressed in placenta, heart, kidney and small intestine. Detected at lower levels in neuronal cells in the brain, in skeletal muscle, spleen, liver, testes and colon.
Subcellular Localizations
Cell membrane; Single-pass type II membrane protein. In brain only the membrane-bound form is found. The protein resides in intracellular vesicles together with GLUT4 and can then translocate to the cell surface in response to insulin and/or oxytocin. Localization may be determined by dileucine internalization motifs, and/or by interaction with tankyrases.; [Leucyl-cystinyl aminopeptidase, pregnancy serum form]: Secreted. During pregnancy serum levels are low in the first trimester, rise progressively during the second and third trimester and decrease rapidly after parturition.
Diseases
- Abnormal Behavior
- Traumatic Brain Injury
- Nerve Degeneration
- Substance-related Disorders
- Muscular Atrophy
- Atrophy
- Diabetes Mellitus
- Smallpox
- Brain Damage, Chronic
- Motor Neuron Disease
- Lesion Of Brain
- Diabetes Mellitus, Non-insulin-dependent
Interacting Proteins
- FATE1
- REL
- TCF4
Pathways
- Cytokine Production
- Immune Response
- Social Behavior
- Mating
PTMs
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LNPEP
bosterbio.com/bosterbio-gene-info-cards/LNPEP
References
PMID: 8550619 by Rogi T., et al. Human placental leucine aminopeptidase/oxytocinase. A new member of type II membrane-spanning zinc metallopeptidase family.
PMID: 9177475 by Laustsen P.G., et al. The complete amino acid sequence of human placental oxytocinase.