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LITAF Antibodies
AND LITAF ELISA kits, LITAF Proteins
Many biological assays use antibodies to detect LITAF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LITAF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LITAF antibodies...
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LITAF Overview
Facts about Lipopolysaccharide-induced tumor necrosis factor-alpha factor.
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)
Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation (PubMed:23166352). Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby will help downregulate downstream signaling cascades (PubMed:23166352).
Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes (PubMed:23166352). Probably plays a role in regulating protein degradation via its interaction with NEDD4 (PubMed:15776429).
Gene Information
| Human | |
|---|---|
| Gene Name: | LITAF |
| Uniprot: | Q99732 |
| Entrez: | 9516 |
Family
| Belongs to: |
|---|
| CDIP1/LITAF family |
Alternative Names
CMT1C; FLJ38636; lipopolysaccharide-induced TNF factor; lipopolysaccharide-induced TNF-alpha factor; lipopolysaccharide-induced tumor necrosis factor-alpha factor; LITAF; LPS-induced TNF-alpha factor; MGC116698; MGC116700; MGC125275; MGC125276; p53-induced gene 7 protein; PIG7; PIG7MGC116701; SIMPLE; SIMPLEMGC125274; Small integral membrane protein of lysosome/late endosome; TP53I7; tumor protein p53 inducible protein 7
Molecular Weight
Mass (kDA):
17.107 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.13 |
| Sequence: | 16; NC_000016.10 (11547722..11636377, complement) |
Tissue Specificity
Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
Subcellular Localizations
Cytoplasm. Nucleus. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome membrane. Late endosome membrane. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane. Associated with membranes of lysosomes, early and late endosomes (PubMed:11274176, PubMed:27927196, PubMed:27582497). Can translocate from the cytoplasm into the nucleus (PubMed:15793005). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity).
Diseases
- Charcot-marie-tooth Disease
- Inflammation
- Neoplasms
- Peripheral Neuropathy
- Innate Immune Response
- Inflammatory Response
- Salmonella Infections
- Poultry Diseases
- Charcot-marie-tooth Disease, Type Ic
- Nervousness
- Malignant Neoplasms
- Demyelinating Diseases
Interacting Proteins
- BAG3
- CALCOCO2
- HGS
- HPCAL4
- NEDD4
- REEP6
- STAM2
- TSG101
- UBQLN1
- WWOX
Pathways
- Localization
- Immune Response
- Pathogenesis
- Inflammatory Response
- Innate Immune Response
- Secretion
- Transport
- Reverse Transcription
- Cytokine Production
- Cell Proliferation
- Methylation
- Acute Inflammatory Response
- Aging
PTMs
- Phosphorylation
- Methylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LITAF
bosterbio.com/bosterbio-gene-info-cards/LITAF
References
PMID: 9305847 by Polyak K., et al. A model for p53-induced apoptosis.
PMID: 10200294 by Myokai F., et al. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment.