LIPA Antibodies

AND LIPA ELISA kits, LIPA Proteins

Many biological assays use antibodies to detect LIPA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LIPA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LIPA antibodies...

We validate the specificity of these antibodies to LIPA by testing them on tissues known to express LIPA positively and negatively. Browse below to find the LIPA antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LIPA Infographic by Boster Bio

All LIPA Products

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Anti-LAL LIPA Monoclonal Antibody

4 Q&As

Human

$399
Cat # A03895
100μl

Anti-LIPA Antibody

Human, Rat

IHC, WB

$405
Cat # A03895-1
100ul

LIPA Overview

Facts about Lysosomal acid lipase/cholesteryl ester hydrolase.

LIPA 3D structure. Source: alphafold

Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)

Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides which were internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.

Gene Information

Human
Gene Name:	LIPA
Uniprot:	P38571
Entrez:	3988

Family

Belongs to:

AB hydrolase superfamily

Alternative Names

Acid cholesteryl ester hydrolase; CESD; Cholesteryl esterase; EC 3.1.1; EC 3.1.1.13; LALCESDcholesterol ester hydrolase; LIPA; Lipase A; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase; lysosomal acid lipase/cholesteryl ester hydrolase; Sterol esterase

Molecular Weight

Mass (kDA):
45.419 kDA

Genomic Context


Human

Location:	10q23.31
Sequence:	10; NC_000010.11 (89213569..89252039, complement)

Subcellular Localizations

Lysosome.

Diseases

Wolman Disease
Cholesterol Ester Storage Disease
Storage Disease
Hepatitis
Hepatitis C
Infective Disorder
Carcinoma
Hiv Infections
Neoplasms
Liver Carcinoma
Liver Neoplasms
Alzheimer's Disease
Atherosclerosis

Hepatitis C, Chronic
Liver Diseases
Papillomavirus Infections
Tuberculosis
Fibrosis
Hepatomegaly
Inflammation

Pathways

Secretion
Pathogenesis
Virulence
Drug Resistance
Transport
Fermentation
Protein Secretion
Cell Growth
Cell Proliferation
Membrane Fusion
Regulation Of Gene Expression
Translation
Biofilm Formation

Cell Adhesion
Cell Migration
Developmental Process
Quorum Sensing
Anaerobic Respiration
Acetate To Acetyl-coa
Response To Paclitaxel

PTMs

Cleavage

Phosphorylation

Decarboxylation

Research Areas

Lipid and Metabolism

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIPA

References

PMID: 1718995 by Anderson R.A., et al. Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases.

PMID: 8112342 by Ameis D., et al. Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase.