LIM domain kinase 2 Antibodies

AND LIMK2 ELISA kits, LIM domain kinase 2 Proteins

Many biological assays use antibodies to detect LIM domain kinase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LIM domain kinase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LIM domain kinase 2 antibodies...

We validate the specificity of these antibodies to LIM domain kinase 2 by testing them on tissues known to express LIMK2 positively and negatively. Browse below to find the LIMK2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LIMK2 Infographic by Boster Bio

All LIMK2 Products

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Product

Figures

Specificity

Applications

Price

Anti-LIM kinase 2/LIMK2 Antibody Picoband®

6 Q&As

Human, Mouse

$370
Cat # PB9717
100 μg/vial

Anti-LIM domain kinase 2 LIMK2 Antibody

Human, Mouse, Rat

IF, IHC, WB

$360
Cat # A03511
100 µl

LIMK1/2 (Phospho-Thr505) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2452
1 kit, containing two 96-well plates and all necessary reagents

Anti-LIMK2 (phospho-T505) Antibody

Human, Mouse, Rat

IF, IHC, WB

$482
Cat # A03511T505
100ul

Anti-Phospho-LIMK-2 (S283) Antibody

Human, Monkey, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A03511S283
100ul

LIM kinase 2 (LIMK2) (NM_001031801) Human Over-expression Lysate

Human

$628
Cat # LS003985
100 µg

LIMK2 Overview

Facts about LIM domain kinase 2.

LIMK2 3D structure. Source: alphafold

LIM domain kinase 2 (LIMK2)

Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. .

Gene Information

Human
Gene Name:	LIMK2
Uniprot:	P53671
Entrez:	3985

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11.1; LIM domain kinase 2; LIMK-2

Molecular Weight

Mass (kDA):
72.232 kDA

Genomic Context


Human

Location:	22q12.2
Sequence:	22; NC_000022.11 (31212298..31280080)

Tissue Specificity

Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed.

Subcellular Localizations

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle.; [Isoform LIMK2a]: Cytoplasm. Nucleus. Isoform LIMK2a is distributed in the cytoplasm and the nucleus.; [Isoform LIMK2b]: Cytoplasm. Nucleus. Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Tissue Adhesions
Neoplasm Metastasis
Cell Invasion
Carcinoma
Nervousness
Cell Transformation, Neoplastic
Neurofibromatoses
Prostatic Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Hereditary Diseases

Neurofibromatosis 1
Malignant Paraganglionic Neoplasm
Hypertrophy
Diabetes Mellitus, Experimental
Williams Syndrome
Tumor Progression
Neuroblastoma

Interacting Proteins

HSP90AB1

Pathways

Localization
Cell Cycle
Spermatogenesis
Cell Proliferation
Mitosis
Cell Migration
Actin Cytoskeleton Reorganization
Cell Death
Rna Interference
Cell Adhesion
Interphase
Meiosis
Tight Junction Assembly

Cell Motility
Oncogenesis
Telophase
Anaphase
Cell Cycle Arrest
Prophase
Nuclear Import

PTMs

Phosphorylation
Dephosphorylation

Cleavage
Acetylation

Research Areas

Breast Cancer
Cancer
Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LIMK2

References

PMID: 8537403 by Okano I., et al. Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.

PMID: 8954941 by Osada H., et al. Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation.