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LILRB2 Antibodies
AND LILRB2 ELISA kits, LILRB2 Proteins
Many biological assays use antibodies to detect LILRB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LILRB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LILRB2 antibodies...
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LILRB2 Infographic by Boster Bio
All LILRB2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$750
Cat # EK2124
96 wells/kit, with removable strips.
Cat # EK2124
96 wells/kit, with removable strips.
Cynomolgus monkey, Human, Mouse
ELISA, Flow Cytometry, FTA
$349
Cat # M04141
100 μg
Cat # M04141
100 μg
LILRB2 Overview
Facts about Leukocyte immunoglobulin-like receptor subfamily B member 2.
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2)
Receptor for class I MHC antigens.
Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042, PubMed:16455647).
Gene Information
| Human | |
|---|---|
| Gene Name: | LILRB2 |
| Uniprot: | Q8N423 |
| Entrez: | 10288 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD85 antigen-like family member D; CD85d antigen; CD85d; Ig-like transcript 4; ILT4; ILT-4; ILT4CD85d; Immunoglobulin-like transcript 4; Leukocyte immunoglobulin-like receptor 2; leukocyte immunoglobulin-like receptor subfamily B member 2 soluble isoform; leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains); LILRB2; LIR2; LIR2CD85D; LIR-2subfamily A (with TM domain), member 6; member 2; MIR10; MIR10LILRA6; Monocyte/macrophage immunoglobulin-like receptor 10
Molecular Weight
Mass (kDA):
65.039 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19q13.42 |
| Sequence: | 19; NC_000019.10 (54273812..54281178, complement) |
Tissue Specificity
Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells (PubMed:20448110). Expressed in myeloid-derived suppressor cells during pregnancy (PubMed:27859042). Detected at low levels in natural killer (NK) cells. Expressed in B cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Decreased Immunologic Activity [pe]
- Autoimmune Reaction
- Inflammation
- Neoplasm Metastasis
- Autoimmune Diseases
- Arthritis
- Cell Invasion
- Infective Disorder
- Hiv Infections
- Autoimmunity
Interacting Proteins
- ANGPTL2
- ANGPTL5
- APP
- HLA-B
- HLA-B
- HLA-G
- NOTCH1
- PTPN6
Pathways
- Immune Response
- Cell Activation
- Tolerance Induction
- T Cell Activation
- Cell Differentiation
- Pathogenesis
- Cytokine Production
- Secretion
- Cytokine Secretion
- Leukocyte Activation
- T Cell Proliferation
- Cell Proliferation
- Cytolysis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LILRB2
bosterbio.com/bosterbio-gene-info-cards/LILRB2
References
PMID: 9382880 by Colonna M., et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells.
PMID: 9548455 by Borges L., et al. A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules.